Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | brain aging is associated with a decrease of pyruvate dehydrogenase activity upon phosphorylation of the E1alpha subunit. Decreases in activity of about 25% and about 45% are found in mitochondria from 14- and 24-months old rats, respectively. The pyruvate dehydrogenase kinase-2-dependent inhibition of PDH activity amounts to about 20%, 43%, and 49% at 6, 14, and 24 months of age, respectively | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + CoA + NAD+ | - |
Rattus norvegicus | acetyl-CoA + CO2 + NADH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDH | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus | |
thiamine diphosphate | - |
Rattus norvegicus |