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Literature summary for 1.2.1.104 extracted from

  • Zhou, Q.; Lam, P.Y.; Han, D.; Cadenas, E.
    Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging (2009), FEBS Lett., 583, 1132-1140.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Rattus norvegicus 5739
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein brain aging is associated with a decrease of pyruvate dehydrogenase activity upon phosphorylation of the E1alpha subunit. Decreases in activity of about 25% and about 45% are found in mitochondria from 14- and 24-months old rats, respectively. The pyruvate dehydrogenase kinase-2-dependent inhibition of PDH activity amounts to about 20%, 43%, and 49% at 6, 14, and 24 months of age, respectively Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + CoA + NAD+
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Rattus norvegicus acetyl-CoA + CO2 + NADH
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?

Synonyms

Synonyms Comment Organism
PDH
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Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
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Rattus norvegicus
thiamine diphosphate
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Rattus norvegicus