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Literature summary for 1.2.1.104 extracted from

  • Butler, M.H.; Mell, G.P.; Wright, B.E.
    The pyruvate dehydrogenase complex in Dictyostelium discoideum (1985), Curr. Top. Cell. Regul., 26, 337-346.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by ATP Dictyostelium discoideum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.14
-
 pyruvate assay with whole enzyme complex Dictyostelium discoideum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Dictyostelium discoideum 5739
-

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information not regulated by phosphorylation/dephosphorylation Dictyostelium discoideum

Purification (Commentary)

Purification (Comment) Organism
pyruvate dehydrogenase complex composed of EC 1.2.4.1, EC 2.3.1.12, EC 1.8.1.4 Dictyostelium discoideum

Storage Stability

Storage Stability Organism
-50°C, 50 mM potassium phosphate buffer, pH 7.2, 10% glycerol, 1 mM DTT, several months Dictyostelium discoideum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + CoA + NAD+
-
 Dictyostelium discoideum acetyl-CoA + CO2 + NADH + H+
-
 r