Literature summary for 1.2.1.104 extracted from

Yeaman, S.J.
The mammalian 2-oxoacid dehydrogenases: a complex family (1986), Trends Biochem. Sci., 11, 293-296.

No PubMed abstract available

Search for more literature for 1.2.1.104

Inhibitors

Inhibitors	Comment	Organism	Structure
phosphorylation	-	Bos taurus
phosphorylation	-	Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
additional information	-	-	Sus scrofa
additional information	-	MW of native complex isolated from kidney and heart: 7000000 Da and 8500000 Da respectively	Bos taurus
36000	-	alpha2,beta2, 2 * 41000 + 2 * 36000	Bos taurus
36000	-	60 * 41000 (E1 alpha) + 60 * 36000 (E1 beta) + 60 * 52000 (E2, EC 2.3.1.12) + 12 * 55000 (E3, EC 1.8.1.4) + 8-12 * 50000 (component X) + kinase and phosphatase components, heart pyruvate dehydrogenase complex	Bos taurus
41000	-	alpha2,beta2, 2 * 41000 + 2 * 36000	Bos taurus
41000	-	60 * 41000 (E1 alpha) + 60 * 36000 (E1 beta) + 60 * 52000 (E2, EC 2.3.1.12) + 12 * 55000 (E3, EC 1.8.1.4) + 8-12 * 50000 (component X) + kinase and phosphatase components, heart pyruvate dehydrogenase complex	Bos taurus
50000	-	60 * 41000 (E1 alpha) + 60 * 36000 (E1 beta) + 60 * 52000 (E2, EC 2.3.1.12) + 12 * 55000 (E3, EC 1.8.1.4) + 8-12 * 50000 (component X) + kinase and phosphatase components, heart pyruvate dehydrogenase complex	Bos taurus
52000	-	60 * 41000 (E1 alpha) + 60 * 36000 (E1 beta) + 60 * 52000 (E2, EC 2.3.1.12) + 12 * 55000 (E3, EC 1.8.1.4) + 8-12 * 50000 (component X) + kinase and phosphatase components, heart pyruvate dehydrogenase complex	Bos taurus
55000	-	60 * 41000 (E1 alpha) + 60 * 36000 (E1 beta) + 60 * 52000 (E2, EC 2.3.1.12) + 12 * 55000 (E3, EC 1.8.1.4) + 8-12 * 50000 (component X) + kinase and phosphatase components, heart pyruvate dehydrogenase complex	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	overview	-
Sus scrofa	-	overview	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
side-chain modification	-	Bos taurus
side-chain modification	inactivated by phosphorylation	Sus scrofa

Subunits

Subunits	Comment	Organism
oligomer	-	Sus scrofa
oligomer	60 * 41000 (E1 alpha) + 60 * 36000 (E1 beta) + 60 * 52000 (E2, EC 2.3.1.12) + 12 * 55000 (E3, EC 1.8.1.4) + 8-12 * 50000 (component X) + kinase and phosphatase components, heart pyruvate dehydrogenase complex	Bos taurus
tetramer	alpha2,beta2, 2 * 41000 + 2 * 36000	Bos taurus

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Release 2023.1 (January 2023)