BRENDA - Enzyme Database show
show all sequences of 1.17.99.3

Substrate specificity of THCA-CoA oxidases from rat liver light mitochondrial fractions on dehydrogenation of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid CoA thioester

Ikegawa, S.; Goto, T.; Mano, N.; Goto, J.; Steroids 63, 603-607 (1998)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor
the 25S epimer is a preferential substrate
660513
Rattus norvegicus
(24R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor
-
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor
the 25S epimer is a preferential substrate
660513
Rattus norvegicus
(24R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor
-
-
-
?
Other publictions for EC 1.17.99.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
660513
Ikegawa
Substrate specificity of THCA- ...
Rattus norvegicus
Steroids
63
603-607
1998
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1
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1
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1
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1
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-
1
-
-
-
-
-
-
-
-
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-
-
-
-
659132
Pedersen
Molecular cloning and expressi ...
Oryctolagus cuniculus
J. Biol. Chem.
272
18481-18489
1997
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
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1
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1
1
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1
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1
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1
1
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657715
Pedersen
Substrate stereospecificity in ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
224
37-42
1996
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-
-
-
-
-
-
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1
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1
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1
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1
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1
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1
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657799
Baumgart
Molecular cloning and further ...
Rattus norvegicus
Biochem. J.
320
115-121
1996
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1
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1
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1
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658589
Dieuaide-Noubhani
Further characterization of th ...
Rattus norvegicus
Eur. J. Biochem.
240
660-666
1996
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-
-
-
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1
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1
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1
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1
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658691
van Veldhoven
Peroxisomal beta-oxidation of ...
Rattus norvegicus
FEBS Lett.
388
80-84
1996
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1
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1
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1
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1
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1
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657798
van Veldhoven
Purification and further chara ...
Rattus norvegicus
Biochem. J.
304
195-200
1994
5
-
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1
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1
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3
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6
1
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1
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1
1
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4
1
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1
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5
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1
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1
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1
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3
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6
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1
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1
1
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4
1
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659122
Van Veldhoven
Substrate specificities of rat ...
Rattus norvegicus
J. Biol. Chem.
267
20065-20074
1992
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1
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1
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391048
Schepers
Presence of three acyl-CoA oxi ...
Rattus norvegicus
J. Biol. Chem.
265
5242-5246
1990
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1
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1
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1
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1
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659657
Casteels
Separate peroxisomal oxidases ...
Homo sapiens
J. Lipid Res.
31
1865-1872
1990
-
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659120
Casteels
Inhibition of 3alpha,7alpha,12 ...
Rattus norvegicus
J. Biol. Chem.
263
4654-4661
1988
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1
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659114
Gustafsson
Biosynthesis of cholic acid in ...
Rattus norvegicus
J. Biol. Chem.
250
8243-8247
1975
3
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