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Literature summary for 1.17.99.2 extracted from
- Ab initio modeling of ethylbenzene dehydrogenase reaction mechanism (2010), J. Am. Chem. Soc., 132, 6014-6024.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Molybdenum | molybdopterin enzyme | Aromatoleum aromaticum |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Aromatoleum aromaticum | EBDH is a bacterial molybdopterin enzyme capable of stereospecific anaerobic hydroxylation of alkylaromatic compounds to secondary alcohols | ? | - |
? | |
| ethylbenzene + H2O + acceptor | Aromatoleum aromaticum | - |
(S)-1-phenylethanol + reduced acceptor | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aromatoleum aromaticum | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | EBDH is a bacterial molybdopterin enzyme capable of stereospecific anaerobic hydroxylation of alkylaromatic compounds to secondary alcohols | Aromatoleum aromaticum | ? | - |
? | |
| ethylbenzene + H2O + acceptor | - |
Aromatoleum aromaticum | (S)-1-phenylethanol + reduced acceptor | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ethylbenzene dehydrogenase | - |
Aromatoleum aromaticum |
| EBDH | - |
Aromatoleum aromaticum |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 9 | - |
Aromatoleum aromaticum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| molybdenum cofactor | - |
Aromatoleum aromaticum | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | EBDH is a bacterial molybdopterin enzyme capable of stereospecific anaerobic hydroxylation of alkylaromatic compounds to secondary alcohols. It is a key biocatalyst in the metabolism of ethylbenzene-degrading bacteria such as Aromatoleum aromaticum, which converts ethylbenzene to (S)-1-phenylethanol | Aromatoleum aromaticum |
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Release 2022.2 (July 2022)
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