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Literature summary for 1.17.7.1 extracted from

  • Saggu, G.S.; Garg, S.; Pala, Z.R.; Yadav, S.K.; Kochar, S.K.; Kochar, D.K.; Saxena, V.
    Characterization of 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (IspG) from Plasmodium vivax and its potential as an antimalarial drug target (2017), Int. J. Biol. Macromol., 96, 466-473 .
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Plasmodium vivax

Localization

Localization Comment Organism GeneOntology No. Textmining
apicoplast
-
 Plasmodium vivax 20011
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized ferredoxin Plasmodium vivax
-
 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced ferredoxin
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium vivax
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography, and Superdex 200 gel filtration Plasmodium vivax

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized ferredoxin
-
 Plasmodium vivax 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced ferredoxin
-
 ?

Subunits

Subunits Comment Organism
? x * 100000, SDS-PAGE Plasmodium vivax
? x * 98700, calculated from amino acid sequence Plasmodium vivax

Synonyms

Synonyms Comment Organism
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
-
 Plasmodium vivax
GcpE
-
 Plasmodium vivax
IspG
-
 Plasmodium vivax

Cofactor

Cofactor Comment Organism Structure
[4Fe-4S]-center
-
 Plasmodium vivax