Literature summary for 1.17.4.4 extracted from

Hatahet, F.; Blazyk, J.L.; Martineau, E.; Mandela, E.; Zhao, Y.; Campbell, R.E.; Beckwith, J.; Boyd, D.
Altered Escherichia coli membrane protein assembly machinery allows proper membrane assembly of eukaryotic protein vitamin K epoxide reductase (2015), Proc. Natl. Acad. Sci. USA, 112, 15184-15189 .

Cloned(Commentary)

Cloned (Comment)	Organism
genetic selection for mutants of Escherichia coli that promote the efficient membrane integration and expression of the mammalian membrane protein vitamin K epoxide reductase (VKORc1), that is ordinarily barely expressed in a wild-type Escherichia coli. When this poorly expressed enzyme is mutagenized or introduced to a library of Escherichia coli mutants, functional expression is achieved. The results suggest that YidC may play a role in quality control of membrane proteins at the level of insertion. Alteration of this function can greatly enhance functional overexpression of other membrane proteins	Rattus norvegicus

Cloned (Comment)

Organism

genetic selection for mutants of Escherichia coli that promote the efficient membrane integration and expression of the mammalian membrane protein vitamin K epoxide reductase (VKORc1), that is ordinarily barely expressed in a wild-type Escherichia coli. When this poorly expressed enzyme is mutagenized or introduced to a library of Escherichia coli mutants, functional expression is achieved. The results suggest that YidC may play a role in quality control of membrane proteins at the level of insertion. Alteration of this function can greatly enhance functional overexpression of other membrane proteins

Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
warfarin	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q6TEK4	-	-

Synonyms

Synonyms	Comment	Organism
vitamin K epoxide reductase	-	Rattus norvegicus
VKORC1	-	Rattus norvegicus

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Release 2023.1 (January 2023)