Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
A143V | mutant shows about 140% relative VKOR activity as compared to the wild type enzyme | Rattus norvegicus |
A26S | mutant shows about 70% relative VKOR activity as compared to the wild type enzyme | Mus musculus |
A26T | mutant shows about 60% relative VKOR activity as compared to the wild type enzyme | Rattus norvegicus |
A26T | the mutation has only a moderate effect on VKOR activity with a reduction to approximately 56% of wild type activity | Rattus norvegicus |
A48T | mutant shows about 120% relative VKOR activity as compared to the wild type enzyme | Mus musculus |
E37G | mutant shows about 75% relative VKOR activity as compared to the wild type enzyme | Mus musculus |
E67K | the mutant shows a reduced vitamin K epoxide turnover of about 33% compared to the wild type protein, and has no effect on warfarin sensitivity in vitro | Rattus norvegicus |
F63C | the mutation reduces the VKOR activity to about 30% of normal | Rattus norvegicus |
I141V | mutant shows about 45% relative VKOR activity as compared to the wild type enzyme | Rattus norvegicus |
I90L | mutant shows about 90% relative VKOR activity as compared to the wild type enzyme | Rattus norvegicus |
L128Q | mutant shows moderately reduced VKOR activity (about 60% compared to wild type protein) and is resistant to warfarin inhibition to a variable degree | Rattus norvegicus |
L128S | mutant shows about 20% relative VKOR activity as compared to the wild type enzyme | Mus musculus |
R12W | mutant shows about 35% relative VKOR activity as compared to the wild type enzyme | Mus musculus |
R33P | VKOR activity of the Arg33Pro variant is reduced to 42% of wild type activity | Rattus norvegicus |
R58G | mutant shows about 40% relative VKOR activity as compared to the wild type enzyme | Mus musculus |
R61L | mutant shows about 50% relative VKOR activity as compared to the wild type enzyme | Mus musculus |
W59R | mutant shows 16% residual VKOR activity | Rattus norvegicus |
Y139C | mutant shows about 30% relative VKOR activity as compared to the wild type enzyme | Mus musculus |
Y139C | mutant shows moderately reduced VKOR activity (about 60% compared to wild type protein) and is resistant to warfarin inhibition to a variable degree | Rattus norvegicus |
Y139S | mutant shows moderately reduced VKOR activity and is resistant to warfarin inhibition to a variable degree | Rattus norvegicus |
Y39N | mutant shows about 30% relative VKOR activity as compared to the wild type enzyme | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
warfarin | almost complete inhibition at 0.06 mM | Mus musculus | |
warfarin | almost complete inhibition at 0.06 mM | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
vitamin K 2,3-epoxide + dithiothreitol | - |
Mus musculus | vitamin K + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | - |
Rattus norvegicus | vitamin K + oxidized dithiothreitol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Vitamin K reductase | - |
Mus musculus |
Vitamin K reductase | - |
Rattus norvegicus |
vitamin K-epoxide reductase | - |
Mus musculus |
vitamin K-epoxide reductase | - |
Rattus norvegicus |
VKOR | - |
Mus musculus |
VKOR | - |
Rattus norvegicus |
VKORC1 | - |
Mus musculus |
VKORC1 | - |
Rattus norvegicus |