Literature summary for 1.17.4.4 extracted from

Lasseur, R.; Grandemange, A.; Longin-Sauvageon, C.; Berny, P.; Benoit, E.
Comparison of the inhibition effect of different anticoagulants on vitamin K epoxide reductase activity from warfarin-susceptible and resistant rat (2007), Pestic. Biochem. Physiol., 88, 203-208.

No PubMed abstract available

Search for more literature for 1.17.4.4

Protein Variants

Protein Variants	Comment	Organism
Y139F	highly resistant to warfarin and increased resistance to further anticoagulants	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
brodifacoum	-	Rattus norvegicus
bromadiolone	-	Rattus norvegicus
chlorophacinone	-	Rattus norvegicus
coumachlor	-	Rattus norvegicus
coumatetralyl	-	Rattus norvegicus
Difenacoum	-	Rattus norvegicus
diphacinone	-	Rattus norvegicus
warfarin	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00004	-	brodifacoum	wild-type, pH 7.4, 30°C	Rattus norvegicus
0.00007	-	Difenacoum	wild-type, pH 7.4, 30°C	Rattus norvegicus
0.00007	-	diphacinone	wild-type, pH 7.4, 30°C	Rattus norvegicus
0.00008	-	chlorophacinone	wild-type, pH 7.4, 30°C	Rattus norvegicus
0.00009	-	brodifacoum	mutant Y139F, pH 7.4, 30°C	Rattus norvegicus
0.00012	-	coumachlor	wild-type, pH 7.4, 30°C	Rattus norvegicus
0.00013	-	bromadiolone	wild-type, pH 7.4, 30°C	Rattus norvegicus
0.00013	-	coumatetralyl	wild-type, pH 7.4, 30°C	Rattus norvegicus
0.00026	-	Difenacoum	mutant Y139F, pH 7.4, 30°C	Rattus norvegicus
0.00072	-	warfarin	wild-type, pH 7.4, 30°C	Rattus norvegicus
0.00091	-	bromadiolone	mutant Y139F, pH 7.4, 30°C	Rattus norvegicus
0.0016	-	chlorophacinone	mutant Y139F, pH 7.4, 30°C	Rattus norvegicus
0.0019	-	coumachlor	mutant Y139F, pH 7.4, 30°C	Rattus norvegicus
0.0031	-	coumatetralyl	mutant Y139F, pH 7.4, 30°C	Rattus norvegicus
0.005	-	diphacinone	mutant Y139F, pH 7.4, 30°C	Rattus norvegicus
0.029	-	warfarin	mutant Y139F, pH 7.4, 30°C	Rattus norvegicus

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Release 2023.1 (January 2023)