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Literature summary for 1.17.4.4 extracted from

  • Wilson, C.R.; Sauer, J.M.; Carlson, G.P.; Wallin, R.; Ward, M.P.; Hooser, S.B.
    Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition (2003), Toxicology, 189, 191-198.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
warfarin IC50: 0.00007 mM Bos taurus
warfarin
-
Canis lupus familiaris
warfarin
-
Equus caballus
warfarin IC50: 0.00018 mM, only one sample measured Homo sapiens
warfarin IC50: 0.00017 mM Mus musculus
warfarin
-
Ovis aries
warfarin IC50: 0.00012 mM, only one sample measured Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00241
-
vitamin K1 2,3-epoxide 37°C Ovis aries
0.00241
-
vitamin K1 2,3-epoxide 37°C Equus caballus
0.00309
-
vitamin K1 2,3-epoxide 37°C, only one sample measured Homo sapiens
0.0032
-
vitamin K1 2,3-epoxide 37°C, only one sample measured Sus scrofa
0.0036
-
vitamin K1 2,3-epoxide 37°C Canis lupus familiaris
0.00416
-
vitamin K1 2,3-epoxide 37°C Mus musculus
0.00425
-
vitamin K1 2,3-epoxide 37°C Bos taurus
0.00646
-
vitamin K1 2,3-epoxide 37°C Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Mus musculus
-
-
microsome
-
Homo sapiens
-
-
microsome
-
Sus scrofa
-
-
microsome
-
Bos taurus
-
-
microsome
-
Ovis aries
-
-
microsome
-
Canis lupus familiaris
-
-
microsome
-
Equus caballus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Canis lupus familiaris
-
-
-
Equus caballus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Ovis aries
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
liver
-
Sus scrofa
-
liver
-
Bos taurus
-
liver
-
Ovis aries
-
liver
-
Canis lupus familiaris
-
liver
-
Equus caballus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vitamin K1 2,3-epoxide + dithiothreitol
-
Mus musculus vitamin K1 + oxidized dithiothreitol
-
?
vitamin K1 2,3-epoxide + dithiothreitol
-
Homo sapiens vitamin K1 + oxidized dithiothreitol
-
?
vitamin K1 2,3-epoxide + dithiothreitol
-
Sus scrofa vitamin K1 + oxidized dithiothreitol
-
?
vitamin K1 2,3-epoxide + dithiothreitol
-
Bos taurus vitamin K1 + oxidized dithiothreitol
-
?
vitamin K1 2,3-epoxide + dithiothreitol
-
Ovis aries vitamin K1 + oxidized dithiothreitol
-
?
vitamin K1 2,3-epoxide + dithiothreitol
-
Canis lupus familiaris vitamin K1 + oxidized dithiothreitol
-
?
vitamin K1 2,3-epoxide + dithiothreitol
-
Equus caballus vitamin K1 + oxidized dithiothreitol
-
?

Synonyms

Synonyms Comment Organism
VKOR
-
Mus musculus
VKOR
-
Homo sapiens
VKOR
-
Sus scrofa
VKOR
-
Bos taurus
VKOR
-
Ovis aries
VKOR
-
Canis lupus familiaris
VKOR
-
Equus caballus
warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
Mus musculus
warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
Homo sapiens
warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
Sus scrofa
warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
Bos taurus
warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
Ovis aries
warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
Canis lupus familiaris
warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
Equus caballus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00007
-
IC50: 0.00007 mM Bos taurus warfarin
0.00012
-
IC50: 0.00012 mM, only one sample measured Sus scrofa warfarin
0.00017
-
IC50: 0.00017 mM Mus musculus warfarin
0.00018
-
IC50: 0.00018 mM, only one sample measured Homo sapiens warfarin