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Literature summary for 1.17.4.4 extracted from
- Effect of N-ethylmaleimide on beef and rat liver vitamin K1 epoxide reductase (1990), J. Enzyme Inhib., 3, 289-294.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-ethylmaleimide | protected by vitamin K 2,3-epoxide | Bos taurus |  |
| N-ethylmaleimide | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | integral membrane protein | Rattus norvegicus | - |
- |
| microsome | integral membrane protein | Bos taurus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| phylloquinone + a protein with a disulfide bond + H2O = 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues | ping-pong mechanism | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| vitamin K 2,3-epoxide + dithiothreitol | - |
Rattus norvegicus | vitamin K + oxidized dithiothreitol | - |
? | |
| vitamin K 2,3-epoxide + dithiothreitol | - |
Bos taurus | vitamin K + oxidized dithiothreitol | - |
? | |
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Release 2023.1 (January 2023)
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