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Literature summary for 1.17.4.2 extracted from

  • Saiko, P.; Pemberger, M.; Horvath, Z.; Savinc, I.; Grusch, M.; Handler, N.; Erker, T.; Jaeger, W.; Fritzer-Szekeres, M.; Szekeres, T.
    Novel resveratrol analogs induce apoptosis and cause cell cycle arrest in HT29 human colon cancer cells: inhibition of ribonucleotide reductase activity (2008), Oncol. Rep., 19, 1621-1626.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
3,3',4,4',5,5'-hexahydroxy-trans-stilbene i.e. M8, a resveratrol analogue, inhibits the enzyme and causes an imbalance of intracellular dNTP pools, the dATP pool is eliminated, while the dCTP and dTTP pools are enlarged. M8 leads to complete growth inhibition of HT-29 cells at 0.015 mM within 7 days, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme produces deoxyribonucleotide triphosphates, dNTPs ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
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 Homo sapiens
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HT-29 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme produces deoxyribonucleotide triphosphates, dNTPs Homo sapiens ?
-
 ?