Literature summary for 1.17.4.2 extracted from

Sigmond, J.; Kamphuis, J.A.; Laan, A.C.; Hoebe, E.K.; Bergman, A.M.; Peters, G.J.
The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent (2007), Biochem. Pharmacol., 73, 1548-1557.

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Inhibitors

Inhibitors	Comment	Organism	Structure
gemcitabine	-	Homo sapiens
additional information	no enzyme inhibition by arabinoside cytosine	Homo sapiens
triapine	i.e. 3-AP, triapine enhances the cytotoxicity of gemcitabine and arabinoside cytosine in four non-small-cell-lung-cancer cell lines, e.g. in SW1573 cells, but not in H460 cells, multiple-drug-effect analysis, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
additional information	RNR expression in small cell lung cancer cell lines, overview	Homo sapiens	-
NCI-H292 cell	-	Homo sapiens	-
NCI-H460 cell	-	Homo sapiens	-
SW-1573 cell	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
tetramer	RNR is a tetramer consisting of two non-identical homodimers. The two identical M2 subunits regulate the substrate specificity of the enzyme, while the other two identical M1 subunits are responsible for the activity by binding the ribonucleotides and allosteric effectors	Homo sapiens

Synonyms

Synonyms	Comment	Organism
RNR	-	Homo sapiens

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Release 2023.1 (January 2023)