Protein Variants | Comment | Organism |
---|---|---|
additional information | in p53null cells, siRNA-mediated knockdown of about 80% of R2 subunits has no effect on proliferative growth but results in enhanced accumulation of gamma-H2Ax and delayed recovery from DNA lesions inflicted by exposure to cisplatin and Triapine. Level of R1 subunits is limiting since depletion of the R1 subunit directly activates the S phase checkpoint due to replication stress | Homo sapiens |
Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | colon cancer cell. Cell line expresses subunit R2 in excess resulting in protection against DNA damage and replication stress | Homo sapiens | - |