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Literature summary for 1.17.4.2 extracted from

  • Lin, Z.P.; Belcourt, M.F.; Carbone, R.; Eaton, J.S.; Penketh, P.G.; Shadel, G.S.; Cory, J.G.; Sartorelli, A.C.
    Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress (2007), Biochem. Pharmacol., 73, 760-772.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information in p53null cells, siRNA-mediated knockdown of about 80% of R2 subunits has no effect on proliferative growth but results in enhanced accumulation of gamma-H2Ax and delayed recovery from DNA lesions inflicted by exposure to cisplatin and Triapine. Level of R1 subunits is limiting since depletion of the R1 subunit directly activates the S phase checkpoint due to replication stress Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell colon cancer cell. Cell line expresses subunit R2 in excess resulting in protection against DNA damage and replication stress Homo sapiens
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