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Literature summary for 1.17.4.1 extracted from

  • Graser-Loescher, G.; Schoenhuber, A.; Ciglenec, C.; Eberl, S.; Krupitza, G.; Mader, R.M.; Jadav, S.S.; Jayaprakash, V.; Fritzer-Szekeres, M.; Szekeres, T.; Saiko, P.
    Thiosemicarbazone derivatives, thiazolyl hydrazones, effectively inhibit leukemic tumor cell growth Down-regulation of ribonucleotide reductase activity and synergism with arabinofuranosylcytosine (2017), Food Chem. Toxicol., 108, 53-62 .
    View publication on PubMed

Application

Application Comment Organism
drug development the thiazolyl hydrazones VG12, VG19, and VG22 plus arabinofuranosylcytosine might be able to improve conventional chemotherapeutic regimens for the treatment of human malignancies such as acute promyelocytic or chronic myelogenous leukemia Homo sapiens
medicine the thiazolyl hydrazones VG12, VG19, and VG22 plus arabinofuranosylcytosine might be able to improve conventional chemotherapeutic regimens for the treatment of human malignancies such as acute promyelocytic or chronic myelogenous leukemia Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P23921 ribonucleoside-diphosphate reductase large subunit
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Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
class I ribonucleotide reductase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the thiazolyl hydrazone VG19 lowers the protein levels of ribonucleotide reductase subunits R1 and R2 and significantly diminishes the incorporation of radio-labeled 14C cytidine, being equivalent to an inhibition of DNA synthesis down
Homo sapiens the thiazolyl hydrazone VG19 lowers the protein levels of ribonucleotide reductase subunits R1 and R2 and significantly diminishes the incorporation of radio-labeled 14Ccytidine, being equivalent to an inhibition of DNA synthesis down

General Information

General Information Comment Organism
metabolism constitutive ribonucleotide reductase activity ensures stable and balanced dNTP production, which is essential for de novo DNA synthesis. The enzyme is responsible for the rate-limiting step of de novo DNA synthesis Homo sapiens
metabolism constitutive RNR activity ensures stable and balanced dNTP production, which is essential for de novo DNA synthesis. The enzyme is responsible for the rate-limiting step of de novo DNA synthesis Homo sapiens
metabolism provides the precursors necessary for DNA synthesis. Constitutive ribonucleotide reductase activity ensures stable and balanced dNTP production, which is essential for de novo DNA synthesis. The enzyme is responsible for the rate-limiting step of de novo DNA synthesis Homo sapiens