Application | Comment | Organism |
---|---|---|
drug development | the thiazolyl hydrazones VG12, VG19, and VG22 plus arabinofuranosylcytosine might be able to improve conventional chemotherapeutic regimens for the treatment of human malignancies such as acute promyelocytic or chronic myelogenous leukemia | Homo sapiens |
medicine | the thiazolyl hydrazones VG12, VG19, and VG22 plus arabinofuranosylcytosine might be able to improve conventional chemotherapeutic regimens for the treatment of human malignancies such as acute promyelocytic or chronic myelogenous leukemia | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P23921 | ribonucleoside-diphosphate reductase large subunit | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
class I ribonucleotide reductase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the thiazolyl hydrazone VG19 lowers the protein levels of ribonucleotide reductase subunits R1 and R2 and significantly diminishes the incorporation of radio-labeled 14C cytidine, being equivalent to an inhibition of DNA synthesis | down |
Homo sapiens | the thiazolyl hydrazone VG19 lowers the protein levels of ribonucleotide reductase subunits R1 and R2 and significantly diminishes the incorporation of radio-labeled 14Ccytidine, being equivalent to an inhibition of DNA synthesis | down |
General Information | Comment | Organism |
---|---|---|
metabolism | constitutive ribonucleotide reductase activity ensures stable and balanced dNTP production, which is essential for de novo DNA synthesis. The enzyme is responsible for the rate-limiting step of de novo DNA synthesis | Homo sapiens |
metabolism | constitutive RNR activity ensures stable and balanced dNTP production, which is essential for de novo DNA synthesis. The enzyme is responsible for the rate-limiting step of de novo DNA synthesis | Homo sapiens |
metabolism | provides the precursors necessary for DNA synthesis. Constitutive ribonucleotide reductase activity ensures stable and balanced dNTP production, which is essential for de novo DNA synthesis. The enzyme is responsible for the rate-limiting step of de novo DNA synthesis | Homo sapiens |