Literature summary for 1.17.4.1 extracted from

Martin, J.E.; Imlay, J.A.
The alternative aerobic ribonucleotide reductase of Escherichia coli, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvation (2011), Mol. Microbiol., 80, 319-334.

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P39452	isoform NrdE	-

Synonyms

Synonyms	Comment	Organism
NrdE	-	Escherichia coli

Expression

Organism	Comment	Expression
Escherichia coli	isoform NrdEF is induced during H2O2 stress. Induction is mediated by the inactivation of Fur, an iron-dependent repressor. NrdEF supports cell replication in iron-depleted cells. Iron binds to NrdF when it is expressed in iron-rich cells, but NrdEF is functional only in cells that are both iron-depleted and manganese-rich	up

General Information

General Information	Comment	Organism
physiological function	isoform NrdEF is induced during H2O2 stress. Induction is mediated by the inactivation of Fur, an iron-dependent repressor. NrdEF supports cell replication in iron-depleted cells. Iron binds to NrdF when it is expressed in iron-rich cells, but NrdEF is functional only in cells that are both iron-depleted and manganese-rich	Escherichia coli

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Release 2023.1 (January 2023)