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Literature summary for 1.17.4.1 extracted from

  • Riera, J.; Robb, F.T.; Weiss, R.; Fontecave, M.
    Ribonucleotide reductase in the archaeon Pyrococcus furiosus: a critical enzyme in the evolution of DNA genomes? (1997), Proc. Natl. Acad. Sci. USA, 94, 475-478.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.17.4.1

Cloned(Commentary)

Cloned (Comment) Organism
-
 Pyrococcus furiosus

Inhibitors

Inhibitors Comment Organism Structure
dATP
-
 Pyrococcus furiosus

Organism

Organism UniProt Comment Textmining
Pyrococcus furiosus E7FHX6
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Pyrococcus furiosus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.51
-
 pH 7.5, 80°C Pyrococcus furiosus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP + reduced dithiothreitol
-
 Pyrococcus furiosus 2'-dCDP + oxidized dithiothreitol + H2O
-
 ?

Synonyms

Synonyms Comment Organism
ribonucleotide reductase
-
 Pyrococcus furiosus
RNR
-
 Pyrococcus furiosus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
80
-
 assay at Pyrococcus furiosus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Pyrococcus furiosus

Cofactor

Cofactor Comment Organism Structure
adenosylcobalamin absolutely requires adenosylcobalamin (as a radical generator) for activity, KM: 0.001 mM Pyrococcus furiosus