Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Chlamydia trachomatis | |
additional information | the R2 protein of class I RNR contains a Mn-Fe instead of the standard Fe-Fe cofactor. Ct R2 has a redox-inert phenylalanine replacing the radical-forming tyrosine of classic RNRs, which implies a different mechanism of O2 activation, overview | Chlamydia trachomatis |
Crystallization (Comment) | Organism |
---|---|
subunit R2, X-ray diffraction structure determination and analysis at 2.75-2.90 A resolution | Chlamydia trachomatis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Hydroxyurea | - |
Chlamydia trachomatis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | metal content determination of oxidized and reduced subunit R2, electronic features and nuclear geometry of the manganese and iron sites, kinetics, overview. The R2 protein of class I RNR contains a Mn-Fe instead of the standard Fe-Fe cofactor. Ct R2 has a redox-inert phenylalanine replacing the radical-forming tyrosine of classic RNRs, which implies a different mechanism of O2 activation, overview. Structure modelling | Chlamydia trachomatis | |
Mg2+ | activates | Chlamydia trachomatis | |
Mn2+ | metal content determination of oxidized and reduced subunit R2, electronic features and nuclear geometry of the manganese and iron sites, kinetics, overview. The R2 protein of class I RNR contains a Mn-Fe instead of the standard Fe-Fe cofactor. Ct R2 has a redox-inert phenylalanine replacing the radical-forming tyrosine of classic RNRs, which implies a different mechanism of O2 activation, overview. Structure modelling | Chlamydia trachomatis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chlamydia trachomatis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | substrate is CDP, R2 is the catalytic subunit | Chlamydia trachomatis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterotetramer | R1R2 complex | Chlamydia trachomatis |
Synonyms | Comment | Organism |
---|---|---|
class I ribonucleotide reductase | - |
Chlamydia trachomatis |
ribonucleotide reductase | - |
Chlamydia trachomatis |
RNR | - |
Chlamydia trachomatis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Chlamydia trachomatis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Mn-Fe cofactor | the R2 protein of class I RNR contains a Mn-Fe instead of the standard Fe-Fe cofactor. Ct R2 has a redox-inert phenylalanine replacing the radical-forming tyrosine of classic RNRs, which implies a different mechanism of O2 activation, overview | Chlamydia trachomatis |