Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of His6-tagged subunits M2, p53R2, and M1 in Escherichia coli strain BL21(DE3) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,5-diaminopyridine-2-carboxaldehyde thiosemicarbazone | - |
Homo sapiens | |
3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone | - |
Homo sapiens | |
3-aminopyridine-2-carboxaldehyde thiosemicarbazone | triapine | Homo sapiens | |
3-methyl aminopyridine-2-carboxaldehyde thiosemicarbazone | - |
Homo sapiens | |
5-amino-4-morpholinomethylpyridine-2-carboxaldehyde thiosemicarbazone | - |
Homo sapiens | |
5-aminopyridine-2-carboxaldehyde thiosemicarbazone | - |
Homo sapiens | |
5-hydroxy-4-methyl-1-formylisoquinoline thiosemicarbazone | - |
Homo sapiens | |
5-methyl-4-amino-1-formylisoquinoline thiosemicarbazone | - |
Homo sapiens | |
gemcitabine | - |
Homo sapiens | |
Hydroxyurea | - |
Homo sapiens | |
additional information | inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe3+ | - |
Homo sapiens | |
Mg2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant His6-tagged subunits M2, p53R2, and M1 from Escherichia coli strain BL21(DE3) by nickel affinity chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
KB cell | nasopharyngeal carcinoma cells, a gemcitabine-resistant cell line | Homo sapiens | - |
nasopharyngeal carcinoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | dCDP is produced from CDP by the holoenzyme | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | the enzyme consists of M1, M2, and p53R2 subunits in an alphabeta2gamma constellation | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ribonucleotide reductase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
catalytic activity and ligand binding assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
catalytic activity assay at | Homo sapiens |
7.5 | - |
ligand binding assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in DNA replication and damage repair, respectively | Homo sapiens |