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Literature summary for 1.17.4.1 extracted from
- Enzymatic synthesis of deoxyribonucleotides. IX. Allosteric effects in the reduction of pyrimidine ribonucleotides by the ribonucleoside diphosphate reductase system of Escherichia coli (1966), J. Biol. Chem., 241, 2533-2539.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dATP | inhibition of CDP and UDP reduction is reversed by ATP; inhibition of CDP reduction; inhibition of UDP reduction | Escherichia coli |  |
| GDP | - |
Escherichia coli | |
| UDP | - |
Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0015 | - |
dTTP | positive effector of CDP reduction | Escherichia coli | |
| 0.07 | - |
ATP | positive effector of CDP reduction | Escherichia coli | |
| 0.22 | - |
UDP | - |
Escherichia coli | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | subunit B1 requires Mg2+ ions in the 10 mM concentration range for activity | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ribonucleoside diphosphate + reduced thioredoxin | - |
Escherichia coli | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
| UDP + reduced thioredoxin | - |
Escherichia coli | 2'-deoxy-UDP + oxidized thioredoxin + H2O | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.007 | - |
GDP | competitive vs. CDP | Escherichia coli | |
| 0.5 | - |
UDP | competitive vs. CDP | Escherichia coli | |
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