Activating Compound | Comment | Organism | Structure |
---|---|---|---|
adenyl-5'-yl-imidodiphosphate | can replace ATP as activator of CDP and UDP reduction | Mus musculus | |
ADP | - |
Mus musculus | |
dGDP | 40% less effective than dGTP | Mus musculus | |
dGTP | activation of ADP reduction | Mus musculus | |
additional information | overview: nucleoside 5'-diphosphates as effectors of mammalian ribonucleotide reductase | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dATP | inhibition of CDP reduction; inhibition of CDP, UDP, GDP and ADP reduction; noncompetitive inhibition vs. ADP, GDP and CDP | Mus musculus | |
dGTP | inhibition of GDP reduction | Mus musculus | |
dTTP | inhibition of ADP- CDP- and UDP reduction | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | model of enzyme regulation by nucleoside 5'-triphosphates | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
Ehrlich ascites tumor cells | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Ehrlich ascites carcinoma cell | - |
Mus musculus | - |
L-1210 cell | - |
Mus musculus | - |
L-cell | cell line | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ribonucleoside diphosphate + reduced thioredoxin | - |
Mus musculus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir |