Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.17.4.1 extracted from

  • Cory, J.G.; Sato, A.; Brown, N.C.
    Protein properties of the subunits of ribonucleotide reductase and the specificity of the allosteric site(s) (1986), Adv. Enzyme Regul., 25, 3-19.
    View publication on PubMed
Search for more literature for 1.17.4.1

Activating Compound

Activating Compound Comment Organism Structure
dITP activation of ADP reduction Mus musculus
additional information stimulation by effector nucleotides Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
2',3'-dideoxy-ATP less potent inhibitor than dATP, 0.1 mM, 50% inhibition of CDP reduction Mus musculus
butylphenyl-dGTP 0.13 mM, 50% inhibition of ADP reduction Mus musculus
dATP inhibition of CDP, UDP, GDP and ADP reduction Mus musculus
dITP inhibition of CDP reduction Mus musculus
N-ethylmaleimide 0.1 mM, 50% inhibition of intact enzyme, 0.05 mM, 50% inhibition of effector-binding subunit, 0.3 mM, 50% inhibition of non-heme iron subunit Mus musculus
p-chloromercuribenzoate 0.35 mM, 50% inhibition of intact enzyme, 0.15 mM, 50% inhibition of effector-binding subunit, 1.5 mM, 50% inhibition of non-heme iron subunit Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ribonucleoside diphosphate + reduced thioredoxin Mus musculus enzyme catalyzes the first unique step in DNA synthesis 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 Ehrlich ascites tumor cells
-

Source Tissue

Source Tissue Comment Organism Textmining
Ehrlich ascites carcinoma cell
-
 Mus musculus
-
L-1210 cell
-
 Mus musculus
-
L-cell cell line Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ribonucleoside diphosphate + reduced thioredoxin
-
 Mus musculus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
ribonucleoside diphosphate + reduced thioredoxin enzyme catalyzes the first unique step in DNA synthesis Mus musculus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ?