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Literature summary for 1.17.4.1 extracted from

  • Huszar, D.; Bacchetti, S.
    Is ribonucleotide reductase the transforming function of herpes simplex virus 2? (1983), Nature, 302, 77-79.
No PubMed abstract available
Search for more literature for 1.17.4.1

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme does not respond to feedbck inhibition by dTTP or dATP Herpes simplex virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ribonucleoside diphosphate + reduced thioredoxin Herpes simplex virus possible role in HSV-2-induced transformation 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ?
ribonucleoside diphosphate + reduced thioredoxin Herpes simplex virus enzyme catalyzes the first unique step in DNA synthesis 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Herpes simplex virus
-
 type 2, HSV-2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ribonucleoside diphosphate + reduced thioredoxin
-
 Herpes simplex virus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
ribonucleoside diphosphate + reduced thioredoxin possible role in HSV-2-induced transformation Herpes simplex virus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ?
ribonucleoside diphosphate + reduced thioredoxin enzyme catalyzes the first unique step in DNA synthesis Herpes simplex virus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ?