Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | reduction of CDP and UDP requires 1-2 mM ATP | Rattus norvegicus | |
ATP | further stimulation of dTTP activated GDP reduction | Rattus norvegicus | |
dATP | stimulation of GDP reduction | Rattus norvegicus | |
dGTP | required for ADP reduction, maximal activity with 0.01 mM dGTP | Rattus norvegicus | |
dTTP | stimulation of GDP reduction | Rattus norvegicus | |
dTTP | absolutely required for GDP reduction, less than 10% activity in the absence of dTTP, maximal stimulation with 0.001-0.1 mM dTTP in the absence of ATP and 0.1-1 mM in the presence of ATP, inhibition above | Rattus norvegicus | |
dTTP | required for ADP reduction | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dATP | inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction; inhibition of UDP reduction | Rattus norvegicus | |
dGTP | inhibition of CDP reduction; inhibition of GDP reduction; inhibition of UDP reduction | Rattus norvegicus | |
dTTP | inhibition of CDP reduction; inhibition of UDP reduction | Rattus norvegicus | |
dUTP | inhibition of: CDP reduction, UDP reduction | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | effect of different nucleoside triphosphates on Km | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ribonucleoside diphosphate + reduced thioredoxin | - |
Rattus norvegicus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir |