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Literature summary for 1.17.4.1 extracted from

  • Moore, E.C.; Hurlbert, R.B.
    Regulation of mammalian deoxyribonucleotide biosynthesis by nucleotides as activators and inhibitors (1966), J. Biol. Chem., 241, 4802-4809.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ATP reduction of CDP and UDP requires 1-2 mM ATP Rattus norvegicus
ATP further stimulation of dTTP activated GDP reduction Rattus norvegicus
dATP stimulation of GDP reduction Rattus norvegicus
dGTP required for ADP reduction, maximal activity with 0.01 mM dGTP Rattus norvegicus
dTTP stimulation of GDP reduction Rattus norvegicus
dTTP absolutely required for GDP reduction, less than 10% activity in the absence of dTTP, maximal stimulation with 0.001-0.1 mM dTTP in the absence of ATP and 0.1-1 mM in the presence of ATP, inhibition above Rattus norvegicus
dTTP required for ADP reduction Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
dATP inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction; inhibition of UDP reduction Rattus norvegicus
dGTP inhibition of CDP reduction; inhibition of GDP reduction; inhibition of UDP reduction Rattus norvegicus
dTTP inhibition of CDP reduction; inhibition of UDP reduction Rattus norvegicus
dUTP inhibition of: CDP reduction, UDP reduction Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information effect of different nucleoside triphosphates on Km Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ribonucleoside diphosphate + reduced thioredoxin
-
Rattus norvegicus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
ir