Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.17.3.2 extracted from

  • Baldissera, M.D.; Souza, C.F.; Doleski, P.H.; Monteiro, S.G.; da Silva, A.S.; Baldisserotto, B.
    Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis The influence of these enzymes on inflammatory and oxidative status (2018), J. Fish Dis., 41, 263-268 .
    View publication on PubMed
Search for more literature for 1.17.3.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxanthine + NAD+ + H2O Bagrus bajad
-
 xanthine + NADH + H+
-
 ?
xanthine + H2O + O2 Bagrus bajad
-
 urate + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Bagrus bajad
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Bagrus bajad
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxanthine + NAD+ + H2O
-
 Bagrus bajad xanthine + NADH + H+
-
 ?
xanthine + H2O + O2
-
 Bagrus bajad urate + H2O2
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Bagrus bajad

Expression

Organism Comment Expression
Bagrus bajad the enzyme is upregulated and enzyme activity increases 1.5fold in animals infected with Ichthyophthirius multifiliis compared to uninfected animals, alongside the seric levels of uric acid, metabolites of nitric oxide (NOx) and reactive oxygen species (ROS) up

General Information

General Information Comment Organism
malfunction upregulation of seric XO activity through infection with Ichthyophthirius multifiliis leads to an excessive formation of uric acid, which contributes to oxidative and inflammatory processes. Uric acid induces the release of pro-inflammatory and pro-oxidative mediators, such as nitric oxide (NOx) and reactive oxygen species (ROS), which contribute directly to disease pathogenesis Bagrus bajad