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Literature summary for 1.17.3.2 extracted from

  • Masuoka, N.; Kubo, I.
    Suppression of superoxide anion generation catalyzed by xanthine oxidase with alkyl caffeates and the scavenging activity (2016), Int. J. Food Sci. Nutr., 67, 283-287 .
    View publication on PubMed
Search for more literature for 1.17.3.2

Inhibitors

Inhibitors Comment Organism Structure
3,4-dihydroxyphenyl dodecanoate sigmoidal inhibition of superoxide anion formation Bos taurus
3,4-dihydroxyphenyl octanoate
-
 Bos taurus
butyl caffeate competitive inhibition of urate and superoxide anion formation Bos taurus
caffeic acid competitive inhibition of urate and superoxide anion formation Bos taurus
decyl caffeate competitive inhibition of urate and superoxide anion formation Bos taurus
heptyl caffeate competitive inhibition of urate and superoxide anion formation Bos taurus
hexyl caffeate competitive inhibition of urate and superoxide anion formation Bos taurus
methyl caffeate competitive inhibition of urate and superoxide anion formation Bos taurus
additional information alkyl caffeates are strong antioxidants and inhibitors of xanthine oxidase. Caffeic acid derivatives equally suppressed O2- generation, and the suppression is stronger than inhibition of xanthine oxidase. Suppression of O2- generation catalyzed by xanthine oxidase with caffeic acid derivatives is not due to enzyme inhibition or O2 - scavenging but due to the reduction of xanthine oxidase molecules. Alkyl caffeates are effective inhibitors of uric acid and O2- catalyzed by xanthine oxidase as well as antioxidants for edible oil Bos taurus
octyl protocatechuate competitive inhibition of urate and superoxide anion formation Bos taurus
pentyl caffeate competitive inhibition of urate and superoxide anion formation Bos taurus
propyl caffeate competitive inhibition of urate and superoxide anion formation Bos taurus
propyl protocatechuate sigmoidal inhibition of superoxide anion formation Bos taurus
protocatechuic acid competitive inhibition of urate and superoxide anion formation Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus P80457
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Bos taurus
-
milk
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information scavenging activities of 1,1-diphenyl-2-picryhydrazyl (DPPH) radical and O2 generated with phenazine methosulfate (PMS) and NADH,overview Bos taurus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at, superoxid anion generation by xanthine oxidase Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10
-
 assay at, superoxide anion generation by xanthine oxidase Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0076
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus heptyl caffeate
0.01
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus decyl caffeate
0.01
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus pentyl caffeate
0.0108
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus hexyl caffeate
0.0115
-
 above, pH 10.0, 25°C, inhibition of urate formation Bos taurus caffeic acid
0.0115
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus propyl caffeate
0.012
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus methyl caffeate
0.0125
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus heptyl caffeate
0.0164
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus decyl caffeate
0.018
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus pentyl caffeate
0.019
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus hexyl caffeate
0.022
-
 above, pH 10.0, 25°C, inhibition of urate formation Bos taurus protocatechuic acid
0.026
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus butyl caffeate
0.03
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus propyl caffeate
0.0627
-
 above, pH 10.0, 25°C, inhibition of urate formation Bos taurus propyl protocatechuate
0.082
-
 above, pH 10.0, 25°C, inhibition of urate formation Bos taurus octyl protocatechuate
0.125
-
 above, pH 10.0, 25°C, inhibition of urate formation Bos taurus protocatechuic acid
0.125
-
 above, pH 10.0, 25°C, inhibition of urate formation Bos taurus octyl protocatechuate
0.125
-
 above, pH 10.0, 25°C, inhibition of urate formation Bos taurus propyl protocatechuate
0.143
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus methyl caffeate
0.2
-
 above, pH 10.0, 25°C, inhibition of urate formation Bos taurus caffeic acid
0.2
-
 above, pH 10.0, 25°C, inhibition of urate formation Bos taurus 3,4-dihydroxyphenyl dodecanoate
0.2
-
 above, pH 10.0, 25°C, inhibition of urate formation Bos taurus 3,4-dihydroxyphenyl octanoate
92.5
-
 above, pH 10.0, 25°C, inhibition of urate formation Bos taurus 3,4-dihydroxyphenyl dodecanoate
110
-
 pH 10.0, 25°C, inhibition of urate formation Bos taurus butyl caffeate