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Literature summary for 1.17.3.2 extracted from

  • Zafar, H.; Hayat, M.; Saied, S.; Khan, M.; Salar, U.; Malik, R.; Choudhary, M.I.; Khan, K.M.
    Xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides a systematic approach from in vitro, in silico to in vivo studies (2017), Bioorg. Med. Chem., 25, 2351-2371 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides, in vitro, in silico, and in vivo studies, overview. No inhibition by N'-[(E)-(2-nitrophenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(4-nitrophenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(3-hydroxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2-ethoxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2-methoxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(3,4-dimethoxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2,3,4-trimethoxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2-hydroxy-6-methoxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2-hydroxy-5-methoxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2,4-dichlorophenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2-hydroxy-5-methylphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-[4-(methylsulfanyl)phenyl]methylidene]pyridine-3-carbohydrazide, N'-[(E)-[4-(dimethylamino)phenyl]methylidene]pyridine-3-carbohydrazide, N'-[(E)-phenylmethylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-nitrophenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(4-nitrophenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(4-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(3-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2,4-dihydroxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-ethoxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(3,4-diethoxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(3,4-dimethoxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(4-ethoxy-3-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(3-hydroxy-4-methoxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-hydroxy-5-methoxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-chlorophenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-fluorophenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2,4-dichlorophenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-chloro-5-nitrophenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-[4-(methylsulfanyl)phenyl]methylidene]pyridine-4-carbohydrazide, and N'-[(E)-[4-(dimethylamino)phenyl]methylidene]pyridine-4-carbohydrazide Bos taurus
N'-[(E)-(2,4,6-trihydroxyphenyl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(E)-(2-bromophenyl)methylidene]pyridine-3-carbohydrazide
-
Bos taurus
N'-[(E)-(2-fluorophenyl)methylidene]pyridine-3-carbohydrazide
-
Bos taurus
N'-[(E)-(2-hydroxy-3-methoxyphenyl)methylidene]pyridine-3-carbohydrazide
-
Bos taurus
N'-[(E)-(2-hydroxy-3-methoxyphenyl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(E)-(2-methylphenyl)methylidene]pyridine-3-carbohydrazide
-
Bos taurus
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]pyridine-3-carbohydrazide
-
Bos taurus
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(E)-(3,5-dihydroxyphenyl)methylidene]pyridine-3-carbohydrazide
-
Bos taurus
N'-[(E)-(3-chlorophenyl)methylidene]pyridine-3-carbohydrazide
-
Bos taurus
N'-[(E)-(3-chlorophenyl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]pyridine-3-carbohydrazide
-
Bos taurus
N'-[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(E)-(3-nitrophenyl)methylidene]pyridine-3-carbohydrazide
-
Bos taurus
N'-[(E)-(3-nitrophenyl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(E)-(4-chlorophenyl)methylidene]pyridine-3-carbohydrazide
-
Bos taurus
N'-[(E)-(4-chlorophenyl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(E)-(4-ethoxyphenyl)methylidene]pyridine-3-carbohydrazide
-
Bos taurus
N'-[(E)-(4-ethoxyphenyl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(E)-(4-hydroxyphenyl)methylidene]pyridine-3-carbohydrazide
-
Bos taurus
N'-[(E)-phenylmethylidene]pyridine-3-carbohydrazide
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxanthine + NAD+ + H2O Bos taurus
-
xanthine + NADH + H+
-
?
xanthine + H2O + O2 Bos taurus
-
urate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus P80457
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Bos taurus
-
milk
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxanthine + NAD+ + H2O
-
Bos taurus xanthine + NADH + H+
-
?
xanthine + H2O + O2
-
Bos taurus urate + H2O2
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0009
-
pH 7.4, 30°C Bos taurus N'-[(E)-(2,4,6-trihydroxyphenyl)methylidene]pyridine-4-carbohydrazide
0.01
-
pH 7.4, 30°C Bos taurus N'-[(E)-(3,4-dihydroxyphenyl)methylidene]pyridine-3-carbohydrazide
0.0124
-
pH 7.4, 30°C Bos taurus N'-[(E)-(3,4-dihydroxyphenyl)methylidene]pyridine-4-carbohydrazide
0.021
-
pH 7.4, 30°C Bos taurus N'-[(E)-(2-hydroxy-3-methoxyphenyl)methylidene]pyridine-4-carbohydrazide
0.0211
-
pH 7.4, 30°C Bos taurus N'-[(E)-phenylmethylidene]pyridine-3-carbohydrazide
0.055
-
pH 7.4, 30°C Bos taurus N'-[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide
0.161
-
pH 7.4, 30°C Bos taurus N'-[(E)-(3,5-dihydroxyphenyl)methylidene]pyridine-3-carbohydrazide
0.174
-
pH 7.4, 30°C Bos taurus N'-[(E)-(2-fluorophenyl)methylidene]pyridine-3-carbohydrazide
0.174
-
pH 7.4, 30°C Bos taurus N'-[(E)-(3-nitrophenyl)methylidene]pyridine-4-carbohydrazide
0.1755
-
pH 7.4, 30°C Bos taurus N'-[(E)-(2-hydroxy-3-methoxyphenyl)methylidene]pyridine-3-carbohydrazide
0.179
-
pH 7.4, 30°C Bos taurus N'-[(E)-(4-chlorophenyl)methylidene]pyridine-4-carbohydrazide
0.18
-
pH 7.4, 30°C Bos taurus N'-[(E)-(2-methylphenyl)methylidene]pyridine-3-carbohydrazide
0.184
-
pH 7.4, 30°C Bos taurus N'-[(E)-(3-nitrophenyl)methylidene]pyridine-3-carbohydrazide
0.184
-
pH 7.4, 30°C Bos taurus N'-[(E)-(4-hydroxyphenyl)methylidene]pyridine-3-carbohydrazide
0.195
-
pH 7.4, 30°C Bos taurus N'-[(E)-(4-chlorophenyl)methylidene]pyridine-3-carbohydrazide
0.198
-
pH 7.4, 30°C Bos taurus N'-[(E)-(2-bromophenyl)methylidene]pyridine-3-carbohydrazide
0.205
-
pH 7.4, 30°C Bos taurus N'-[(E)-(3-chlorophenyl)methylidene]pyridine-3-carbohydrazide
0.206
-
pH 7.4, 30°C Bos taurus N'-[(E)-(3-chlorophenyl)methylidene]pyridine-4-carbohydrazide
0.242
-
pH 7.4, 30°C Bos taurus N'-[(E)-(4-ethoxyphenyl)methylidene]pyridine-3-carbohydrazide
0.264
-
pH 7.4, 30°C Bos taurus N'-[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]pyridine-3-carbohydrazide
0.33
-
pH 7.4, 30°C Bos taurus N'-[(E)-(4-ethoxyphenyl)methylidene]pyridine-4-carbohydrazide