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Literature summary for 1.17.3.2 extracted from

  • Chien, S.C.; Yang, C.W.; Tseng, Y.H.; Tsay, H.S.; Kuo, Y.H.; Wang, S.Y.
    Lonicera hypoglauca inhibits xanthine oxidase and reduces serum uric acid in mice (2009), Planta Med., 75, 302-306.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
allopurinol
-
Mus musculus
ioniceraflavone i.e. 5,5'',7,7''-tetrahydroxy-2,2''-di(p-hydroxyphenyl)-2'',3''-dihydro[3,6'']bichromenyl-4,4''-dione, from ethanolic leaf extracts of Lonicera hypoglauca Mus musculus
additional information ethanol leaf extracts of Lonicera hypoglauca, an endemic rattan growing in Taiwan, inhibits xanthine oxidase and reduces serum uric acid in mice, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + O2 + H2O Mus musculus
-
urate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + O2 + H2O
-
Mus musculus urate + H2O2
-
?

Synonyms

Synonyms Comment Organism
XOD
-
Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
IC50 of licewraflavone is 0.00085 mg/ml and for allopurinol is 0.00040 mg/ml Mus musculus additional information

General Information

General Information Comment Organism
malfunction the enzyme is a key enzyme in th epathogenesis of hyperuricemia Mus musculus