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BRENDA support

Literature summary for 1.17.3.2 extracted from

  • Kaszaki, J.; Palasthy, Z.; Erczes, D.; Racz, A.; Torday, C.; Varga, G.; Vecsei, L.; Boros, M.
    Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs (2008), Neurogastroenterol. Motil., 20, 53-62.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information colon obstruction induces a hyperdynamic circulatory reaction, significantly elevated the motility index and increased mucosal leucocyte accumulation and XOR activity, the increase in activity is counteracted by kynurenic acid Canis lupus familiaris

Inhibitors

Inhibitors Comment Organism Structure
Kynurenic acid
-
Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + H2O + O2 Canis lupus familiaris
-
urate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
Canis lupus familiaris
-
intestine
-
Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + H2O + O2
-
Canis lupus familiaris urate + H2O2
-
?
xanthine + H2O + O2 production of superoxide radicals Canis lupus familiaris urate + H2O2
-
?

Synonyms

Synonyms Comment Organism
xanthine oxidoreductase
-
Canis lupus familiaris
XOR
-
Canis lupus familiaris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Canis lupus familiaris