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Literature summary for 1.17.3.2 extracted from

  • Gupta, S.; Rodrigues, L.M.; Esteves, A.P.; Oliveira-Campos, A.M.; Nascimento, M.S.; Nazareth, N.; Cidade, H.; Neves, M.P.; Fernandes, E.; Pinto, M.; Cerqueira, N.M.; Bras, N.
    Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors (2008), Eur. J. Med. Chem., 43, 771-780.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(4'-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
-
Homo sapiens
1-(4'-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
-
Homo sapiens
1-(4'-trifluoromethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
-
Homo sapiens
1-4-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
-
Homo sapiens
4-(4'-aminopyrazolo[3,4-d]pyrimidin-1-yl)-benzonitrile
-
Homo sapiens
5-amino-1-(4'-carboxyphenyl)-1H-pyrazole-4-carbonitrile
-
Homo sapiens
additional information synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as enzyme inhibitors, potencies of the compounds in enzyme inhibition and cell growth inhibition, overview Homo sapiens
N-(4''-carboxyphenyl)-N-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosyl)pyrazolo[3,4-d] pyrimidine
-
Homo sapiens
N-(4'-carboxyphenyl)-1H-4-aminopyrazolo[3,4-d]pyrimidine
-
Homo sapiens
[4'-(4''-aminopyrazolo[3,4-d]pyrimidin-1''-yl)-benzoylamino]-acetic acid methyl ester
-
Homo sapiens
[4'-(5-amino-4-cyanopyrazol-1-yl)-benzoylamino]-acetic acid methyl ester
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0072
-
xanthine
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell tumor cell line Homo sapiens
-
NCI-H460 cell tumor cell line Homo sapiens
-
SF-268 cell tumor cell line Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00008
-
-
Homo sapiens [4'-(4''-aminopyrazolo[3,4-d]pyrimidin-1''-yl)-benzoylamino]-acetic acid methyl ester
0.00018
-
-
Homo sapiens 1-(4'-trifluoromethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
0.0004
-
-
Homo sapiens 4-(4'-aminopyrazolo[3,4-d]pyrimidin-1-yl)-benzonitrile
0.0022
-
-
Homo sapiens 1-(4'-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
0.0174
-
-
Homo sapiens 1-4-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
0.0184
-
-
Homo sapiens N-(4''-carboxyphenyl)-N-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosyl)pyrazolo[3,4-d] pyrimidine
0.0196
-
-
Homo sapiens (4'-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
0.0361
-
-
Homo sapiens 5-amino-1-(4'-carboxyphenyl)-1H-pyrazole-4-carbonitrile
0.0379
-
-
Homo sapiens [4'-(5-amino-4-cyanopyrazol-1-yl)-benzoylamino]-acetic acid methyl ester
0.081
-
-
Homo sapiens N-(4'-carboxyphenyl)-1H-4-aminopyrazolo[3,4-d]pyrimidine