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Literature summary for 1.17.3.2 extracted from

  • Li, H.; Samouilov, A.; Liu, X.; Zweier, J.L.
    Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues (2003), Biochemistry, 42, 1150-1159.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
diphenylene iodonium chloride inhibits nitrate reduction only when NADH is used as reducing substrate and does not inhibit nitrite generation when xanthine is used Bos taurus
oxypurinol
-
Bos taurus
xanthine at high concentrations Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0253
-
2,3-Dihydroxybenzaldehyde in presence of 1.0 mM nitrate Bos taurus
0.86
-
NADH in presence of 1.0 mM nitrate Bos taurus
6.6
-
xanthine in presence of 2 mM NADH Bos taurus
6.8
-
xanthine in presence of 0.5 mM 2,3-dihydroxybenzaldehyde Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Molybdenum nitrate reduction to nitrite as well as nitrite reduction to NO occurs at the molybdenum site Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nitrate + NADH Bos taurus reaction can be an important source of NO production in ischemic tissues nitrite + NAD+ + H2O
-
?
nitrite + NADH Bos taurus reaction can be an important source of NO production in ischemic tissues NO + NAD+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
milk
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nitrate + 2,3-dihydroxybenzaldehyde
-
Bos taurus nitrite + ?
-
?
nitrate + NADH
-
Bos taurus nitrite + NAD+ + H2O
-
?
nitrate + NADH reaction can be an important source of NO production in ischemic tissues Bos taurus nitrite + NAD+ + H2O
-
?
nitrate + xanthine
-
Bos taurus nitrite + urate + ?
-
?
nitrite + NADH
-
Bos taurus NO + NAD+ + H2O
-
?
nitrite + NADH reaction can be an important source of NO production in ischemic tissues Bos taurus NO + NAD+ + H2O
-
?

Synonyms

Synonyms Comment Organism
XO
-
Bos taurus
XOR
-
Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
generation of nitrite or NO Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.08
-
xanthine
-
Bos taurus