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Literature summary for 1.17.3.2 extracted from

  • De Renzo, E.C.
    Chemistry and biochemistry of xanthine oxidase (1956), Adv. Enzymol. Relat. Subj. Biochem., 17, 293-328.
    View publication on PubMed
Search for more literature for 1.17.3.2

Inhibitors

Inhibitors Comment Organism Structure
2-Amino-4-hydroxy-6-formylpterine
-
 Gallus gallus
2-Amino-4-hydroxy-6-formylpterine
-
 Rattus norvegicus
8-Hydroxyquinoline-7-sulfonic acid
-
 Gallus gallus
8-Hydroxyquinoline-7-sulfonic acid
-
 Rattus norvegicus
alloxan
-
 Gallus gallus
alloxan
-
 Rattus norvegicus
arsenite
-
 Bos taurus
arsenite
-
 Rattus norvegicus
ascorbic acid
-
 Rattus norvegicus
Borate
-
 Gallus gallus
Borate
-
 Rattus norvegicus
chalcones
-
 Gallus gallus
chalcones
-
 Rattus norvegicus
copper
-
 Bos taurus
cyanide
-
 Bos taurus
cyanide
-
 Gallus gallus
cyanide
-
 Rattus norvegicus
hydroxylamine
-
 Bos taurus
hydroxylamine
-
 Gallus gallus
hydroxylamine
-
 Rattus norvegicus
Imidazotriazines
-
 Gallus gallus
Imidazotriazines
-
 Rattus norvegicus
isatin
-
 Gallus gallus
isatin
-
 Rattus norvegicus
ninhydrin
-
 Gallus gallus
ninhydrin
-
 Rattus norvegicus
p-chloromercuribenzoate
-
 Bos taurus
p-chloromercuribenzoate
-
 Gallus gallus
p-chloromercuribenzoate
-
 Rattus norvegicus
Tetraethylthiuram disulfide
-
 Gallus gallus
Tetraethylthiuram disulfide
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
 NADPH cofactor 2,6-dichlorophenolindophenol Bos taurus
0.0475
-
 hypoxanthine cofactor 2,6-dichlorophenolindophenol Bos taurus
0.088
-
 xanthine cofactor 2,6-dichlorophenolindophenol Bos taurus
20
-
 aldehyde cofactor 2,6-dichlorophenolindophenol Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Iron iron-molybdenum protein Gallus gallus
Iron iron-molybdenum protein Rattus norvegicus
Iron iron-molybdenum protein Bos taurus
Molybdenum an iron-molybdenum protein Gallus gallus
Molybdenum an iron-molybdenum protein Rattus norvegicus
Molybdenum an iron-molybdenum protein Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
-
 Gallus gallus
additional information
-
-
 Rattus norvegicus
additional information
-
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Gallus gallus
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information
-
 Gallus gallus
additional information
-
 Rattus norvegicus
additional information
-
 Bos taurus
proteolytic modification
-
 Gallus gallus
proteolytic modification
-
 Rattus norvegicus
proteolytic modification
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
milk
-
 Rattus norvegicus
-
milk
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aldehyde + indophenol
-
 Bos taurus ?
-
 r
hypoxanthine + 2 H2O + 2 O2
-
 Gallus gallus urate + 2 H2O2
-
 ?
hypoxanthine + 2 H2O + 2 O2
-
 Rattus norvegicus urate + 2 H2O2
-
 ?
hypoxanthine + 2 H2O + 2 O2
-
 Bos taurus urate + 2 H2O2
-
 ?
NADPH + indophenol
-
 Bos taurus ?
-
 r
xanthine + H2O + O2 electron acceptor O2 Gallus gallus uric acid + H2O2
-
 ?
xanthine + H2O + O2 electron acceptor O2 Rattus norvegicus uric acid + H2O2
-
 ?
xanthine + H2O + O2 electron acceptor O2 Bos taurus uric acid + H2O2
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.28
-
 NADPH cosubstrate cytochrome c Bos taurus
2.57
-
 NADPH cosubstrate indophenol Bos taurus
4.35
-
 hypoxanthine cofactor 2,6-dichlorophenolindophenol Bos taurus
4.92
-
 xanthine (+ O2) Bos taurus
5.25
-
 xanthine cofactor 2,6-dichlorophenolindophenol Bos taurus

Cofactor

Cofactor Comment Organism Structure
FAD flavoprotein Gallus gallus
FAD flavoprotein Rattus norvegicus
FAD flavoprotein Bos taurus