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Literature summary for 1.17.1.9 extracted from
- Characterization of the NAD+ binding site of Candida boidinii formate dehydrogenase by affinity labelling and site-directed mutagenesis (2000), Eur. J. Biochem., 267, 6657-6664.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K360A | unchanged turnover number and Km-values for formate, but shows reduced affinity for NAD+ | [Candida] boidinii |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| oxidized ADP | inactivates by specific reaction at the nucleotide binding site, with negative cooperativity between subunits accounting for appearance of two phases of inactivation, protection by NAD+, NADH and ADP | [Candida] boidinii |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| [Candida] boidinii | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| formate + NAD+ | - |
[Candida] boidinii | CO2 + NADH + H+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
[Candida] boidinii | |
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Release 2023.1 (January 2023)
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