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Literature summary for 1.17.1.9 extracted from
- Steady-state kinetics of formaldehyde dehydrogenase and formate dehydrogenase from a methanol-utilizing yeast, Candida boidinii (1979), Biochim. Biophys. Acta, 566, 12-20.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | inhibition is greater at acidic pH than at neutral pH | [Candida] boidinii |  |
| AMP | - |
[Candida] boidinii | |
| ATP | inhibition is greater at acidic pH than at neutral pH | [Candida] boidinii | |
| CO2 | - |
[Candida] boidinii | |
| NADH | competitive versus NAD+ | [Candida] boidinii | |
| NADPH | - |
[Candida] boidinii | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| formate + NAD+ | [Candida] boidinii | last enzyme of the dissimilatory pathway of the methanol metabolism | CO2 + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| [Candida] boidinii | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| formate + NAD+ = CO2 + NADH + H+ | ordered bi-bi mechanism, NAD+ is the first substrate and NADH is the last product | [Candida] boidinii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| formate + NAD+ | - |
[Candida] boidinii | CO2 + NADH + H+ | - |
? | |
| formate + NAD+ | last enzyme of the dissimilatory pathway of the methanol metabolism | [Candida] boidinii | CO2 + NADH + H+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
[Candida] boidinii | |
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