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Literature summary for 1.17.1.8 extracted from

  • Cala, A.R.; Nadeau, M.T.; Abendroth, J.; Staker, B.L.; Reers, A.R.; Weatherhead, A.W.; Dobson, R.C.; Myler, P.J.; Hudson, A.O.
    The crystal structure of dihydrodipicolinate reductase from the human-pathogenic bacterium Bartonella henselae strain Houston-1 at 2.3 A resolution (2016), Acta Crystallogr. Sect. F, 72, 885-891 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.17.1.8

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 (DE3) R3 Rosetta cells Bartonella henselae

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting-drop vapor-diffusion, protein crystals are grown in conditions consisting of 5%(w/v) PEG 4000, 200 mM sodium acetate, 100 mM sodium citrate tribasic pH 5.5 and are shown to diffract to about 2.3 A resolution. They belong to space group P4(3)22, with unit cell parameters a = 109.38, b = 109.38, c = 176.95 A Bartonella henselae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
 SDS-PAGE Bartonella henselae
114000
-
 size-exclusion chromatography Bartonella henselae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ Bartonella henselae the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
-
 ?
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ Bartonella henselae Houston 1 the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bartonella henselae Q6G2G3
-
-
Bartonella henselae Houston 1 Q6G2G3
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bartonella henselae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways Bartonella henselae (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
-
 ?
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways Bartonella henselae Houston 1 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
-
 ?

Subunits

Subunits Comment Organism
tetramer 4 * 28000, SDS-PAGE Bartonella henselae

Synonyms

Synonyms Comment Organism
DapB
-
 Bartonella henselae

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways Bartonella henselae