Protein Variants | Comment | Organism |
---|---|---|
additional information | isolation of selD and xdh in-frame deletion mutants with null phenotype for biofilm formation. The wild-type strain produces significant levels of superoxide, whereas the selD and xdh mutants do not exhibit superoxide production, overview | Enterococcus faecalis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
selenium | dependent on, selenium is required in a labile form | Enterococcus faecalis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterococcus faecalis | - |
gene xdh | - |
Synonyms | Comment | Organism |
---|---|---|
XDH | - |
Enterococcus faecalis |
General Information | Comment | Organism |
---|---|---|
metabolism | xanthine dehydrogenase activity correlates with the presence of this labile selenoprotein complex and is absent in a selD, encoding selenophosphate synthetase, or an xdh mutant, overview. Peroxide levels are not increased in either the selD or the xdh mutant upon addition of selenite | Enterococcus faecalis |
additional information | biofilm formation is stimulated in the presence of uric acid, Se, and Mo and inhibited by auranofin or tungstate | Enterococcus faecalis |
physiological function | xanthine dehydrogenase is necessary for extracellular superoxide and hydrogen peroxide production by the organism. The selenium-dependent xanthine dehydrogenase triggers biofilm proliferation in Enterococcus faecalis through oxidant production | Enterococcus faecalis |