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Literature summary for 1.17.1.4 extracted from

  • Taibi, G.; Di Gaudio, F.; Nicotra, C.M.
    Xanthine dehydrogenase processes retinol to retinoic acid in human mammary epithelial cells (2008), J. Enzyme Inhib. Med. Chem., 23, 317-327.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cellular retinol binding protein CRBP and CRABP, strictly dependent on Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
oxypurinol complete inhibition at 0.004 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics in presence and absence of cellular retinol binding proteins, apo-CRBP and apo-CRABP, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol immunohistochemic determination Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens xanthine dehydrogenase is the native form of xanthine oxidase, EC 1.17.3.2, conversion causes a loss of the NAD+ binding activity and of the retinol oxidation activity, the conversion with conformational changes is reversible, except for alteration due to proteolytic cleavage ?
-
?
xanthine + NAD+ + H2O Homo sapiens
-
urate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially from mammary gland epithelial cells by gel filtration Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
xanthine + NAD+ + H2O = urate + NADH + H+ reaction mechanism with substrate all-trans-retinol, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelium mammary epithelial cell line Homo sapiens
-
mammary gland
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information xanthine dehydrogenase is the native form of xanthine oxidase, EC 1.17.3.2, conversion causes a loss of the NAD+ binding activity and of the retinol oxidation activity, the conversion with conformational changes is reversible, except for alteration due to proteolytic cleavage Homo sapiens ?
-
?
xanthine + NAD+ + H2O
-
Homo sapiens urate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
Retinol dehydrogenase
-
Homo sapiens
XDH
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens