Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cellular retinol binding protein | CRBP and CRABP, strictly dependent on | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
oxypurinol | complete inhibition at 0.004 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics in presence and absence of cellular retinol binding proteins, apo-CRBP and apo-CRABP, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | immunohistochemic determination | Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | xanthine dehydrogenase is the native form of xanthine oxidase, EC 1.17.3.2, conversion causes a loss of the NAD+ binding activity and of the retinol oxidation activity, the conversion with conformational changes is reversible, except for alteration due to proteolytic cleavage | ? | - |
? | |
xanthine + NAD+ + H2O | Homo sapiens | - |
urate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme partially from mammary gland epithelial cells by gel filtration | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
xanthine + NAD+ + H2O = urate + NADH + H+ | reaction mechanism with substrate all-trans-retinol, overview | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | mammary epithelial cell line | Homo sapiens | - |
mammary gland | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | xanthine dehydrogenase is the native form of xanthine oxidase, EC 1.17.3.2, conversion causes a loss of the NAD+ binding activity and of the retinol oxidation activity, the conversion with conformational changes is reversible, except for alteration due to proteolytic cleavage | Homo sapiens | ? | - |
? | |
xanthine + NAD+ + H2O | - |
Homo sapiens | urate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Retinol dehydrogenase | - |
Homo sapiens |
XDH | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |