Literature summary for 1.17.1.4 extracted from

Isabelle, M.; Vergeade, A.; Moritz, F.; Dautreaux, B.; Henry, J.P.; Lallemand, F.; Richard, V.; Mulder, P.; Thuillez, C.; Monteil, C.
NADPH oxidase inhibition prevents cocaine-induced up-regulation of xanthine oxidoreductase and cardiac dysfunction (2007), J. Mol. Cell. Cardiol., 42, 326-332.

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Application

Application	Comment	Organism
medicine	cocaine-induced cardiac disfunction is associated with an increase in NADPH oxidase and xanthine oxidoreductase activities by 59% and 29%, respectively, and a decrease in catalase activity. Apocynin or allopurinol treatment prevents the cocaine-induced cardiac alteration by restoration of cardiac output, stroke volume and fractional shortening. This is associated with a reduction of the myocardial production of superoxide anions and an enhancement of catalase activity. Apocynin treatment prevents anthine oxidoreductase up-regulation supporting the hypothesis that NADPH oxidase-derived reactive oxygen species play a role in modulating reactive oxygen species production by xanthine oxidoreductase	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
allopurinol	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	treated for 7 days with cocaine, or cocaine with a NADPH oxidase inhibitor apocynin, or cocaine with a xanthine oxidoreductase inhibitor allopurinol	-

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Release 2023.1 (January 2023)