Literature summary for 1.17.1.4 extracted from

Fini, M.A.; Orchard-Webb, D.; Kosmider, B.; Amon, J.D.; Kelland, R.; Shibao, G.; Wright, R.M.
Migratory activity of human breast cancer cells is modulated by differential expression of xanthine oxidoreductase (2008), J. Cell. Biochem., 1005, 1008-1026.

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Application

Application	Comment	Organism
medicine	demonstration of a functional link between xanthine oxidoreductase expression and mammary epithelial cell migration, potential role in enzyme in suppressing breast cancer pathogenesis. Level of xanthine oxidoreductase is markedly reduced in highly invasive mammary tumor cells, and over-expression of enzyme cDNA in cell lines possessing weak expression and high migratory capacity inhibits their migration in vitro	Homo sapiens
medicine	demonstration of a functional link between xanthine oxidoreductase expression and mammary epithelial cell migration, potential role in enzyme in suppressing breast cancer pathogenesis. Over-expression of enzyme cDNA in cell lines possessing weak expression and high migratory capacity inhibits their migration in vitro	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HB4a cell	-	Homo sapiens	-
HC11 cell	-	Mus musculus	-
HC11-C24 cell	-	Mus musculus	-
MCF-10A cell	high level of xanthine oxidoreductase	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)