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Literature summary for 1.17.1.4 extracted from
- Rat liver xanthine oxidoreductase: effect of adenine on the oxidase and dehydrogenase activities (2007), Ital. J. Biochem., 56, 6-17.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenine | presence of adenine in liver extracts causes a 45-60% decrease in xanthine oxidase and in xanthine oxidase plus xanthine dehydrogenase activities, removal by dialysis results in recovery of both activities to almost pre-treatment levels | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| adenine may play a role in preventing the dehydrogenase to oxidase conversion during extract preparation, storage, overnight dialysis and heat treatment | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 24 h, activity of both xanthine oxidase and xanthine oxidase plus dehydrogenase is lower in liver extracts with the combined presence of adenine and dithiotreitol/phenylmethylsulfonyl fluoride | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
30 min, increase in activity of both xanthine oxidase and xanthine oxidase plus dehydrogenase. No increase in presence of adenine | Rattus norvegicus |
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