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Literature summary for 1.17.1.4 extracted from

  • Abdulnour, R.E.; Peng, X.; Finigan, J.H.; Han, E.J.; Hasan, E.J.; Birukov, K.G.; Reddy, S.P.; Watkins, J.E.; Kayyali, U.S.; Garcia, J.G.; Tuder, R.M.; Hassoun, P.M.
    Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways (2006), Am. J. Physiol. Lung Cell Mol. Physiol., 291, L345-L353.
    View publication on PubMed

Application

Application Comment Organism
medicine lung xanthine oxidoreductase activity is significantly increased after 2 h of mechanical ventilation without changes in enzyme expression. Increase occurs via activation of p38 MAP kinase and ERK and plays a critical role in the pathogenesis of pulmonary edema associated with ventilator-induced lung injury Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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with ventilator-induced lung injury
-

Source Tissue

Source Tissue Comment Organism Textmining
lung lung xanthine oxidoreductase activity is significantly increased after 2 h of mechanical ventilation without changes in enzyme expression. Increase occurs via activation of p38 MAP kinase and ERK and plays a critical role in the pathogenesis of pulmonary edema associated with ventilator-induced lung injury Mus musculus
-