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Literature summary for 1.17.1.4 extracted from

  • Ichimori, K.; Fukahori, M.; Nakazawa, H.; Okamoto, K.; Nishino, T.
    Inhibition of xanthine oxidase and xanthine dehydrogenase by nitric oxid (1999), J. Biol. Chem., 274, 7763-7768.
    View publication on PubMed
Search for more literature for 1.17.1.4

Inhibitors

Inhibitors Comment Organism Structure
NO dose-dependent inhibition of xanthine dehydrogenase and oxidase activity, reaction with an essential sulfur in the molybdenum center, that damages the molybdopterin Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Iron-sulfur-center 2 Fe2-S2-clusters Bos taurus
molybdenum-center
-
 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + NAD+ + H2O Bos taurus NAD+-dependent dehydrogenase type D urate + NADH
-
 ?
xanthine + O2 + H2O Bos taurus
-
 urate + O2- + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
milk
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + NAD+ + H2O NAD+-dependent dehydrogenase type D Bos taurus urate + NADH
-
 ?
xanthine + O2 + H2O
-
 Bos taurus urate + O2- + 2 H+
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Bos taurus
NAD+
-
 Bos taurus