Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.17.1.4 extracted from

  • Eger, B.T.; Okamoto, K.; Enroth, C.; Sato, M.; Nishino, T.; Pai, E.F.; Nishino, T.
    Purification, crystallization and preliminary X-ray diffraction studies of xanthine dehydrogenase and xanthine oxidase isolated from bovine milk (2000), Acta Crystallogr. Sect. D, 56, 1656-1658.
No PubMed abstract available

Crystallization (Commentary)

Crystallization (Comment) Organism
batch method, 2.5 and 3.3 A resolution for irreversible proteolytically cleaved xanthine oxidase form, 2.1 A resolution for dehydrogenase form Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Iron-sulfur-center 2 Fe2-S2-clusters, located at the N-terminal 20 kDa domain Bos taurus
molybdenum-center C-terminal 85 kDa molybdopterin-binding domain Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
145000
-
2 * 145000, data from crystallization Bos taurus
290000
-
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxanthine + NAD+ + H2O Bos taurus
-
xanthine + NADH + H+
-
?
xanthine + NAD+ + H2O Bos taurus
-
urate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
milk
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxanthine + NAD+ + H2O
-
Bos taurus xanthine + NADH + H+
-
?
xanthine + NAD+ + H2O
-
Bos taurus urate + NADH
-
?

Subunits

Subunits Comment Organism
dimer 2 * 145000, data from crystallization Bos taurus

Cofactor

Cofactor Comment Organism Structure
FAD one FAD per subunit, central 40 kDa FAD-domain Bos taurus
additional information one molybdopterin-cofactor, two Fe2-S2-cluster, one FAD per subunit Bos taurus
NAD+
-
Bos taurus