BRENDA - Enzyme Database show
show all sequences of 1.17.1.3

Evolutionary and functional characterization of leucoanthocyanidin reductases from Camellia sinensis

Wang, P.; Zhang, L.; Jiang, X.; Dai, X.; Xu, L.; Li, T.; Xing, D.; Li, Y.; Li, M.; Gao, L.; Xia, T.; Planta 247, 139-154 (2018)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene LARa, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, recombinant expression in Escherichia coli, recombinant expression in transgenic Nicotianan tabacum and Arabidopsis thaliana via Agrobacterium tumefaciens strains EHA105 and C58C1?mediated transformation, quantitative real?time PCR enzyme expression analysis. In Arabidopsis thaliana, contents of both insoluble and soluble proanthocyanidins extracted from the seeds are reduced in the overexpressing CsLARs lines compared with wild-type, although CsLARs catalyze leucocyanidins conversion to catechin in vitro, no catechin is detected in any transgenic Arabidopsis thaliana lines. Also no proanthocyanidins are detected in the transgenic tobacco; gene LARb, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, recombinant expression in Escherichia coli, recombinant expression in transgenic Nicotianan tabacum and Arabidopsis thaliana via Agrobacterium tumefaciens strains EHA105 and C58C1-mediated transformation, quantitative real-time PCR enzyme expression analysis. In Arabidopsis thaliana, contents of both insoluble and soluble proanthocyanidins extracted from the seeds are reduced in the overexpressing CsLARs lines compared with wild-type, although CsLARs catalyze leucocyanidins conversion to catechin in vitro, no catechin is detected in any transgenic Arabidopsis thaliana lines. Also no proanthocyanidins are detected in the transgenic tobacco; gene LARc, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, recombinant expression in Escherichia coli, recombinant expression in transgenic Nicotianan tabacum and Arabidopsis thaliana via Agrobacterium tumefaciens strain s EHA105 and C58C1-mediated transformation, quantitative real-time PCR enzyme expression analysis. In Arabidopsis thaliana, contents of both insoluble and soluble proanthocyanidins extracted from the seeds are reduced in the overexpressing CsLARs lines compared with wild-type, although CsLARs catalyze leucocyanidins conversion to catechin in vitro, no catechin is detected in any transgenic Arabidopsis thaliana lines. Also no proanthocyanidins are detected in the transgenic tobacco; gene LARc, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, recombinant expression in Escherichia coli, recombinant expression in transgenic Nicotianan tabacum and Arabidopsis thaliana via Agrobacterium tumefaciens strain s EHA105 and C58C1?mediated transformation, quantitative real?time PCR enzyme expression analysis. In Arabidopsis thaliana, contents of both insoluble and soluble proanthocyanidins extracted from the seeds are reduced in the overexpressing CsLARs lines compared with wild-type, although CsLARs catalyze leucocyanidins conversion to catechin in vitro, no catechin is detected in any transgenic Arabidopsis thaliana lines. Also no proanthocyanidins are detected in the transgenic tobacco
Camellia sinensis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2,3-trans-3,4-cis-leucocyanidin + NADPH + H+
Camellia sinensis
-
(2R,3S)-catechin + NADP+ + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Camellia sinensis
A0A286QXX3
cv. Shuchazao, TRI2043, grown in an experimental tea field at Anhui agricultural university, Hefei, China (east longitude 117.27, north latitude 31.86)
-
Camellia sinensis
A0A286QXY4
cv. Shuchazao, TRI2043, grown in an experimental tea field at Anhui agricultural university, Hefei, China (east longitude 117.27, north latitude 31.86)
-
Camellia sinensis
I1E425
cv. Shuchazao, TRI2043, grown in an experimental tea field at Anhui agricultural university, Hefei, China (east longitude 117.27, north latitude 31.86)
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
leaf
-
Camellia sinensis
-
leaf bud
-
Camellia sinensis
-
additional information
accumulation of catechins is greater in the buds and younger leaves than in the mature leaves, stems and roots; accumulation of catechins is greater in the buds and younger leaves than in the mature leaves, stems and roots; accumulation of catechins is greater in the buds and younger leaves than in the mature leaves, stems and roots
Camellia sinensis
-
root
-
Camellia sinensis
-
stem
young fine shoots; young fine shoots; young fine shoots
Camellia sinensis
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2,3-trans-3,4-cis-leucocyanidin + NADPH + H+
-
746163
Camellia sinensis
(2R,3S)-catechin + NADP+ + H2O
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 36000, about, sequence calculation; x * 37000, about, sequence calculation; x * 43000, about, sequence calculation
Camellia sinensis
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Camellia sinensis
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Camellia sinensis
sequence calculation
-
5.27
Camellia sinensis
sequence calculation
-
5.34
Camellia sinensis
sequence calculation
-
5.43
Cloned(Commentary) (protein specific)
Commentary
Organism
gene LARa, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, recombinant expression in Escherichia coli, recombinant expression in transgenic Nicotianan tabacum and Arabidopsis thaliana via Agrobacterium tumefaciens strains EHA105 and C58C1?mediated transformation, quantitative real?time PCR enzyme expression analysis. In Arabidopsis thaliana, contents of both insoluble and soluble proanthocyanidins extracted from the seeds are reduced in the overexpressing CsLARs lines compared with wild-type, although CsLARs catalyze leucocyanidins conversion to catechin in vitro, no catechin is detected in any transgenic Arabidopsis thaliana lines. Also no proanthocyanidins are detected in the transgenic tobacco
Camellia sinensis
gene LARb, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, recombinant expression in Escherichia coli, recombinant expression in transgenic Nicotianan tabacum and Arabidopsis thaliana via Agrobacterium tumefaciens strains EHA105 and C58C1-mediated transformation, quantitative real-time PCR enzyme expression analysis. In Arabidopsis thaliana, contents of both insoluble and soluble proanthocyanidins extracted from the seeds are reduced in the overexpressing CsLARs lines compared with wild-type, although CsLARs catalyze leucocyanidins conversion to catechin in vitro, no catechin is detected in any transgenic Arabidopsis thaliana lines. Also no proanthocyanidins are detected in the transgenic tobacco
Camellia sinensis
gene LARc, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, recombinant expression in Escherichia coli, recombinant expression in transgenic Nicotianan tabacum and Arabidopsis thaliana via Agrobacterium tumefaciens strain s EHA105 and C58C1-mediated transformation, quantitative real-time PCR enzyme expression analysis. In Arabidopsis thaliana, contents of both insoluble and soluble proanthocyanidins extracted from the seeds are reduced in the overexpressing CsLARs lines compared with wild-type, although CsLARs catalyze leucocyanidins conversion to catechin in vitro, no catechin is detected in any transgenic Arabidopsis thaliana lines. Also no proanthocyanidins are detected in the transgenic tobacco; gene LARc, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, recombinant expression in Escherichia coli, recombinant expression in transgenic Nicotianan tabacum and Arabidopsis thaliana via Agrobacterium tumefaciens strain s EHA105 and C58C1?mediated transformation, quantitative real?time PCR enzyme expression analysis. In Arabidopsis thaliana, contents of both insoluble and soluble proanthocyanidins extracted from the seeds are reduced in the overexpressing CsLARs lines compared with wild-type, although CsLARs catalyze leucocyanidins conversion to catechin in vitro, no catechin is detected in any transgenic Arabidopsis thaliana lines. Also no proanthocyanidins are detected in the transgenic tobacco
Camellia sinensis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Camellia sinensis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2,3-trans-3,4-cis-leucocyanidin + NADPH + H+
Camellia sinensis
-
(2R,3S)-catechin + NADP+ + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
leaf
-
Camellia sinensis
-
leaf bud
-
Camellia sinensis
-
additional information
accumulation of catechins is greater in the buds and younger leaves than in the mature leaves, stems and roots
Camellia sinensis
-
root
-
Camellia sinensis
-
stem
young fine shoots
Camellia sinensis
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2,3-trans-3,4-cis-leucocyanidin + NADPH + H+
-
746163
Camellia sinensis
(2R,3S)-catechin + NADP+ + H2O
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 43000, about, sequence calculation
Camellia sinensis
?
x * 37000, about, sequence calculation
Camellia sinensis
?
x * 36000, about, sequence calculation
Camellia sinensis
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Camellia sinensis
sequence calculation
-
5.27
Camellia sinensis
sequence calculation
-
5.34
Camellia sinensis
sequence calculation
-
5.43
General Information
General Information
Commentary
Organism
evolution
phylogenetic analysis of the LAR family, overview; phylogenetic analysis of the LAR family, overview; phylogenetic analysis of the LAR family, overview. The dicotyledonous LARs can be clustered into two subgroups, which are defined as cluster I and cluster II
Camellia sinensis
malfunction
overexpression of CsLAR causes a decrease in the proanthocyanidins in transgenic plants; overexpression of CsLAR causes a decrease in the proanthocyanidins in transgenic plants; overexpression of CsLAR causes a decrease in the proanthocyanidins in transgenic plants
Camellia sinensis
physiological function
the enzyme is required in the proanthocyanidin biosynthesis; the enzyme is required in the proanthocyanidin biosynthesis; the enzyme is required in the proanthocyanidin biosynthesis
Camellia sinensis
General Information (protein specific)
General Information
Commentary
Organism
evolution
phylogenetic analysis of the LAR family, overview
Camellia sinensis
evolution
phylogenetic analysis of the LAR family, overview. The dicotyledonous LARs can be clustered into two subgroups, which are defined as cluster I and cluster II
Camellia sinensis
malfunction
overexpression of CsLAR causes a decrease in the proanthocyanidins in transgenic plants
Camellia sinensis
physiological function
the enzyme is required in the proanthocyanidin biosynthesis
Camellia sinensis
Other publictions for EC 1.17.1.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746163
Wang
Evolutionary and functional c ...
Camellia sinensis
Planta
247
139-154
2018
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15
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3
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3
9
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743899
Kumar
Pyramiding of tea dihydroflav ...
Camellia sinensis
3 Biotech
7
177
2017
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5
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745825
Zhao
Metabolic characterization of ...
Camellia sinensis
Molecules
22
E2241
2017
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745634
Matsui
Isolation and characterizatio ...
Fagopyrum esculentum
J. Plant Physiol.
205
41-47
2016
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1
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3
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3
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8
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3
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24
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3
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1
3
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745869
Liu
A role for leucoanthocyanidin ...
Medicago truncatula, Medicago truncatula ecotype R108
Nat. Plants
2
16182
2016
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1
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2
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4
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4
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1
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6
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1
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6
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1
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1
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1
3
3
1
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746116
Nemesio-Gorriz
Different alleles of a gene e ...
Picea abies
Plant Physiol.
171
2671-2681
2016
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5
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2
2
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744993
Liao
Molecular characterization of ...
Malus asiatica, Malus asiatica Nakai, Malus domestica, Malus prunifolia, Malus sikkimensis
Front. Plant Sci.
6
243
2015
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4
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15
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745035
Wen
Accumulation of flavanols and ...
Vitis vinifera
Genet. Mol. Res.
14
7687-7695
2015
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728635
Xiao
Transcriptome and biochemical ...
Gossypium hirsutum
PLoS ONE
9
e86344
2014
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746499
Kim
Transcripts of anthocyanidin ...
Fagopyrum tataricum
ScientificWorldJournal
2014
726567
2014
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3
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726337
Wang
Isolation and characterization ...
Populus trichocarpa
PLoS ONE
8
e64664
2013
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727256
Liu
Proanthocyanidin synthesis in ...
Theobroma cacao
BMC Plant Biol.
13
202
2013
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746103
Pang
Mewan, K.M.; Sumner, L.W.; Yu ...
Camellia sinensis
Plant Physiol.
161
1103-1116
2013
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728054
Yuan
Molecular cloning and characte ...
Populus trichocarpa
J. Exp. Bot.
63
2513-2524
2012
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714393
Wang
-
Isolation and expression of ge ...
Diospyros kaki, Diospyros kaki Luotian-tianshi
Biol. Plant.
54
707-710
2010
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715907
Mauge
Crystal structure and catalyti ...
Vitis vinifera
J. Mol. Biol.
397
1079-1091
2010
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