BRENDA - Enzyme Database show
show all sequences of 1.17.1.3

Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana

Xie, D.Y.; Sharma, S.B.; Dixon, R.A.; Arch. Biochem. Biophys. 422, 91-102 (2004)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in Escherichia coli strain BL21(DE3)
Arabidopsis thaliana
expression in Escherichia coli strain DH5alpha, expression as MBT-fusion protein followed by cleavage of the protein tag by Factor Xa protease
Medicago truncatula
Inhibitors
Inhibitors
Commentary
Organism
Structure
(+)-catechin
-
Arabidopsis thaliana
cyanidin
substrate inhibition at high concentration
Arabidopsis thaliana
dihydroquercetin
-
Arabidopsis thaliana
additional information
no inhibition by (+)-catechin and dihydroquercetin
Medicago truncatula
Na+
above 200 mM
Medicago truncatula
pelargonidin
substrate inhibition at high concentration
Arabidopsis thaliana
quercetin
-
Arabidopsis thaliana
quercetin
-
Medicago truncatula
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Arabidopsis thaliana
additional information
-
additional information
enzyme shows typical Michaelis-Menten kinetics for each substrate
Medicago truncatula
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
additional information
enzyme is not affected by Na+ at up to 400 mM
Arabidopsis thaliana
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
cyanidin + NADPH
Arabidopsis thaliana
-
(-)-epicatechin + NADP+ + H2O
i.e. (2R,3R)-3-cis-flavan-3-ol
-
?
cyanidin + NADPH
Medicago truncatula
-
(-)-epicatechin + NADP+ + H2O
i.e. (2R,3R)-3-cis-flavan-3-ol
-
?
additional information
Arabidopsis thaliana
enzyme is involved in the biosynthesis of condensed tannins in the flavonoid pathway converting anthocyanidins into 2,3-cis-flavan-3-ols, overview
?
-
-
-
additional information
Medicago truncatula
enzyme is involved in the biosynthesis of condensed tannins in the flavonoid pathway converting anthocyanidins into 2,3-cis-flavan-3-ols, overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Arabidopsis thaliana
-
cv. Columbia, gene BANYULS
-
Medicago truncatula
-
gene BANYULS
-
Purification (Commentary)
Commentary
Organism
recombinant enzyme from Escherichia coli
Arabidopsis thaliana
recombinant enzyme from Escherichia coli
Medicago truncatula
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cyanidin + NADPH
-
654366
Arabidopsis thaliana
(-)-epicatechin + NADP+ + H2O
i.e. (2R,3R)-3-cis-flavan-3-ol
-
-
?
cyanidin + NADPH
-
654366
Medicago truncatula
(-)-epicatechin + NADP+ + H2O
i.e. (2R,3R)-3-cis-flavan-3-ol
-
-
?
cyanidin + NADPH
-
654366
Arabidopsis thaliana
(-)-epicatechin + (-)-catechin + NADP+ + H2O
(-)-epicatechin, i.e. (2R,3R)-3-cis-flavan-3-ol, is the major product, formation of (-)-catechin by nonenzymatic epimerization is possible
-
-
?
cyanidin + NADPH
-
654366
Medicago truncatula
(-)-epicatechin + (-)-catechin + NADP+ + H2O
(-)-epicatechin, i.e. (2R,3R)-3-cis-flavan-3-ol, is the major product, formation of (-)-catechin by nonenzymatic epimerization is possible
-
-
?
delphinidin + NADPH
-
654366
Arabidopsis thaliana
(-)-epigallocatechin + (-)-gallocatechin + NADP+ + H2O
(-)-epigallocatechin is the major product, formation of (-)-gallocatechin by nonenzymatic epimerization is possible
-
-
?
delphinidin + NADPH
-
654366
Medicago truncatula
(-)-epigallocatechin + (-)-gallocatechin + NADP+ + H2O
(-)-epigallocatechin is the major product, formation of (-)-gallocatechin by nonenzymatic epimerization is possible
-
-
?
additional information
enzyme is involved in the biosynthesis of condensed tannins in the flavonoid pathway converting anthocyanidins into 2,3-cis-flavan-3-ols, overview
654366
Arabidopsis thaliana
?
-
-
-
-
additional information
enzyme is involved in the biosynthesis of condensed tannins in the flavonoid pathway converting anthocyanidins into 2,3-cis-flavan-3-ols, overview
654366
Medicago truncatula
?
-
-
-
-
additional information
substrate preference in descending order: cyanidin, pelargonidin, delphinidin
654366
Medicago truncatula
?
-
-
-
-
additional information
substrate preference in descending order: delphinidin, pelargonidin, cyanidin
654366
Arabidopsis thaliana
?
-
-
-
-
pelargonidin + NADPH
-
654366
Arabidopsis thaliana
(-)-epiafzelechin + (-)-afzelechin + NADP+ + H2O
(-)-epiafzelechin is the major product, formation of (-)-afzelechin by nonenzymatic epimerization is possible
-
-
?
pelargonidin + NADPH
-
654366
Medicago truncatula
(-)-epiafzelechin + (-)-afzelechin + NADP+ + H2O
(-)-epiafzelechin is the major product, formation of (-)-afzelechin by nonenzymatic epimerization is possible
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
45
-
-
Medicago truncatula
55
-
-
Arabidopsis thaliana
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
6
depending on the buffer system used
Medicago truncatula
7
-
assay at
Arabidopsis thaliana
Cofactor
Cofactor
Commentary
Organism
Structure
NADH
-
Medicago truncatula
NADPH
specific for, positive cooperativity
Arabidopsis thaliana
NADPH
slight preference for
Medicago truncatula
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli strain BL21(DE3)
Arabidopsis thaliana
expression in Escherichia coli strain DH5alpha, expression as MBT-fusion protein followed by cleavage of the protein tag by Factor Xa protease
Medicago truncatula
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADH
-
Medicago truncatula
NADPH
specific for, positive cooperativity
Arabidopsis thaliana
NADPH
slight preference for
Medicago truncatula
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(+)-catechin
-
Arabidopsis thaliana
cyanidin
substrate inhibition at high concentration
Arabidopsis thaliana
dihydroquercetin
-
Arabidopsis thaliana
additional information
no inhibition by (+)-catechin and dihydroquercetin
Medicago truncatula
Na+
above 200 mM
Medicago truncatula
pelargonidin
substrate inhibition at high concentration
Arabidopsis thaliana
quercetin
-
Arabidopsis thaliana
quercetin
-
Medicago truncatula
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Arabidopsis thaliana
additional information
-
additional information
enzyme shows typical Michaelis-Menten kinetics for each substrate
Medicago truncatula
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
additional information
enzyme is not affected by Na+ at up to 400 mM
Arabidopsis thaliana
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
cyanidin + NADPH
Arabidopsis thaliana
-
(-)-epicatechin + NADP+ + H2O
i.e. (2R,3R)-3-cis-flavan-3-ol
-
?
cyanidin + NADPH
Medicago truncatula
-
(-)-epicatechin + NADP+ + H2O
i.e. (2R,3R)-3-cis-flavan-3-ol
-
?
additional information
Arabidopsis thaliana
enzyme is involved in the biosynthesis of condensed tannins in the flavonoid pathway converting anthocyanidins into 2,3-cis-flavan-3-ols, overview
?
-
-
-
additional information
Medicago truncatula
enzyme is involved in the biosynthesis of condensed tannins in the flavonoid pathway converting anthocyanidins into 2,3-cis-flavan-3-ols, overview
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant enzyme from Escherichia coli
Arabidopsis thaliana
recombinant enzyme from Escherichia coli
Medicago truncatula
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cyanidin + NADPH
-
654366
Arabidopsis thaliana
(-)-epicatechin + NADP+ + H2O
i.e. (2R,3R)-3-cis-flavan-3-ol
-
-
?
cyanidin + NADPH
-
654366
Medicago truncatula
(-)-epicatechin + NADP+ + H2O
i.e. (2R,3R)-3-cis-flavan-3-ol
-
-
?
cyanidin + NADPH
-
654366
Arabidopsis thaliana
(-)-epicatechin + (-)-catechin + NADP+ + H2O
(-)-epicatechin, i.e. (2R,3R)-3-cis-flavan-3-ol, is the major product, formation of (-)-catechin by nonenzymatic epimerization is possible
-
-
?
cyanidin + NADPH
-
654366
Medicago truncatula
(-)-epicatechin + (-)-catechin + NADP+ + H2O
(-)-epicatechin, i.e. (2R,3R)-3-cis-flavan-3-ol, is the major product, formation of (-)-catechin by nonenzymatic epimerization is possible
-
-
?
delphinidin + NADPH
-
654366
Arabidopsis thaliana
(-)-epigallocatechin + (-)-gallocatechin + NADP+ + H2O
(-)-epigallocatechin is the major product, formation of (-)-gallocatechin by nonenzymatic epimerization is possible
-
-
?
delphinidin + NADPH
-
654366
Medicago truncatula
(-)-epigallocatechin + (-)-gallocatechin + NADP+ + H2O
(-)-epigallocatechin is the major product, formation of (-)-gallocatechin by nonenzymatic epimerization is possible
-
-
?
additional information
enzyme is involved in the biosynthesis of condensed tannins in the flavonoid pathway converting anthocyanidins into 2,3-cis-flavan-3-ols, overview
654366
Arabidopsis thaliana
?
-
-
-
-
additional information
enzyme is involved in the biosynthesis of condensed tannins in the flavonoid pathway converting anthocyanidins into 2,3-cis-flavan-3-ols, overview
654366
Medicago truncatula
?
-
-
-
-
additional information
substrate preference in descending order: cyanidin, pelargonidin, delphinidin
654366
Medicago truncatula
?
-
-
-
-
additional information
substrate preference in descending order: delphinidin, pelargonidin, cyanidin
654366
Arabidopsis thaliana
?
-
-
-
-
pelargonidin + NADPH
-
654366
Arabidopsis thaliana
(-)-epiafzelechin + (-)-afzelechin + NADP+ + H2O
(-)-epiafzelechin is the major product, formation of (-)-afzelechin by nonenzymatic epimerization is possible
-
-
?
pelargonidin + NADPH
-
654366
Medicago truncatula
(-)-epiafzelechin + (-)-afzelechin + NADP+ + H2O
(-)-epiafzelechin is the major product, formation of (-)-afzelechin by nonenzymatic epimerization is possible
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
45
-
-
Medicago truncatula
55
-
-
Arabidopsis thaliana
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
6
depending on the buffer system used
Medicago truncatula
7
-
assay at
Arabidopsis thaliana
Other publictions for EC 1.17.1.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746163
Wang
Evolutionary and functional c ...
Camellia sinensis
Planta
247
139-154
2018
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1
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3
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9
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5
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3
1
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1
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3
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3
3
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3
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15
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3
3
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3
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3
9
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-
743899
Kumar
Pyramiding of tea dihydroflav ...
Camellia sinensis
3 Biotech
7
177
2017
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1
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1
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1
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5
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1
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1
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1
1
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745825
Zhao
Metabolic characterization of ...
Camellia sinensis
Molecules
22
E2241
2017
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1
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1
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4
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1
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745634
Matsui
Isolation and characterizatio ...
Fagopyrum esculentum
J. Plant Physiol.
205
41-47
2016
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1
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3
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3
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8
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3
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24
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3
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1
3
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745869
Liu
A role for leucoanthocyanidin ...
Medicago truncatula, Medicago truncatula ecotype R108
Nat. Plants
2
16182
2016
-
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1
-
2
-
-
-
-
-
-
4
-
4
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1
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6
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1
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1
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1
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1
1
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2
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4
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1
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6
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1
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1
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1
3
3
1
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746116
Nemesio-Gorriz
Different alleles of a gene e ...
Picea abies
Plant Physiol.
171
2671-2681
2016
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1
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1
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5
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2
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744993
Liao
Molecular characterization of ...
Malus asiatica, Malus asiatica Nakai, Malus domestica, Malus prunifolia, Malus sikkimensis
Front. Plant Sci.
6
243
2015
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4
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8
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12
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15
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12
15
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745035
Wen
Accumulation of flavanols and ...
Vitis vinifera
Genet. Mol. Res.
14
7687-7695
2015
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1
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2
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3
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2
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1
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2
2
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3
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4
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2
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2
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1
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2
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728635
Xiao
Transcriptome and biochemical ...
Gossypium hirsutum
PLoS ONE
9
e86344
2014
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1
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1
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746499
Kim
Transcripts of anthocyanidin ...
Fagopyrum tataricum
ScientificWorldJournal
2014
726567
2014
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1
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1
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1
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1
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9
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1
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1
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1
1
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1
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1
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9
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1
1
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1
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3
3
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726337
Wang
Isolation and characterization ...
Populus trichocarpa
PLoS ONE
8
e64664
2013
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4
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1
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727256
Liu
Proanthocyanidin synthesis in ...
Theobroma cacao
BMC Plant Biol.
13
202
2013
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1
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4
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4
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1
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1
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1
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1
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4
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1
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1
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1
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746103
Pang
Mewan, K.M.; Sumner, L.W.; Yu ...
Camellia sinensis
Plant Physiol.
161
1103-1116
2013
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1
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1
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5
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1
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1
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1
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1
1
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1
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1
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1
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1
1
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728054
Yuan
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