BRENDA - Enzyme Database show
show all sequences of 1.17.1.3

Proanthocyanidin biosynthesis in plants. Purification of legume leucoanthocyanisdin reductase and molecular cloning of its own cDNA

Tanner, G.J.; Francki, K.T.; Abrahams, S.; Watson, J.M.; Larkin, P.J.; Ashton, A.R.; J. Biol. Chem. 278, 31647-31656 (2003)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
; determination of DNA and amino acid sequences, expression in Escherichia coli strain XL-1 Blue, Nicotiana tabacum, and Trifolium repens, plant transformations via Agrobacterium tumefaciens infection system
Desmodium uncinatum
Crystallization (Commentary)
Crystallization
Organism
near homogeneity
Desmodium uncinatum
Inhibitors
Inhibitors
Commentary
Organism
Structure
2,3-cis-flavan-3,4-diol
slight inhibition
Desmodium uncinatum
2,3-cis-flavan-3-ol
product inhibition
Desmodium uncinatum
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromenium
48% inhibition at 0.006 mM
Desmodium uncinatum
3,4-trans-leucocyanidin
50% inhibition at 0.12 mM
Desmodium uncinatum
3,4-trans-leucopelargonidin
50% inhibition at 0.46 mM
Desmodium uncinatum
afzelechin
50% inhibition at 0.014 mM
Desmodium uncinatum
catechin
50% inhibition at 0.012 mM
Desmodium uncinatum
delphinidin
97% inhibition at 0.06 mM
Desmodium uncinatum
dihydroquercetin
60% inhibition at 0.01 mM
Desmodium uncinatum
epi-gallocatechin
50% inhibition at 1.4 mM
Desmodium uncinatum
eriodictyol
53% inhibition at 0.01 mM
Desmodium uncinatum
gallocatechin
50% inhibition at 0.28 mM
Desmodium uncinatum
additional information
overview: phenylpropanoids
Desmodium uncinatum
NADP+
50% inhibition at 0.5 mM; slight inhibition
Desmodium uncinatum
pelargonidin
55% inhibition at 0.006 mM
Desmodium uncinatum
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0004
-
NADPH
pH 7.0, 30°C
Desmodium uncinatum
0.005
-
3,4-cis-leucodelphinidin
pH 7.0, 30°C; pH 7.0, 30°C
Desmodium uncinatum
0.006
-
2,3-trans-3,4-cis-leucocyanidin
pH 7.0, 30°C
Desmodium uncinatum
0.006
-
3,4-cis-leucoanthocyanidin
pH 7.0, 30°C
Desmodium uncinatum
0.026
-
3,4-cis-leucopelargonidin
pH 7.0, 30°C; pH 7.0, 30°C
Desmodium uncinatum
0.06
-
NADH
pH 7.0, 30°C
Desmodium uncinatum
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
45000
-
1 * 45000, native enzyme, SDS-PAGE; 1 * 45000, SDS-PAGE
Desmodium uncinatum
52000
-
gel filtration; native enzyme, gel filtration
Desmodium uncinatum
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2,3-trans-3,4-cis-leucocyanidin + NADPH
Desmodium uncinatum
-
(2R,3S)-catechin + NADP+ + H2O
-
-
-
3,4-cis-leucoanthocyanidin + NADPH
Desmodium uncinatum
-
2,3-trans-catechin + NADP+ + H2O
no formation of 2,3-cis-epicatechin
-
?
additional information
Desmodium uncinatum
enzyme is involved in the biosynthesis of condensed tannins or proanthocyanidins 3,4-cis-leucoanthocyanidin, first committed step, anthocyanidin pathway overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Desmodium uncinatum
-
-
-
Desmodium uncinatum
Q84V83
-
-
Purification (Commentary)
Commentary
Organism
native enzyme to near homogeneity from leaves, about 48500fold
Desmodium uncinatum
Source Tissue
Source Tissue
Commentary
Organism
Textmining
leaf
; small unexpanded leaflets
Desmodium uncinatum
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
8.7
-
; purified native enzyme, substrate 2,3-trans-3,4-cis-leucoanthocyanidin
Desmodium uncinatum
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2,3-trans-3,4-cis-leucocyanidin + NADPH
-
636457
Desmodium uncinatum
(2R,3S)-catechin + NADP+ + H2O
-
-
-
-
2,3-trans-3,4-cis-leucocyanidin + NADPH
-
636457
Desmodium uncinatum
(2R,3S)-catechin + NADP+ + H2O
-
-
-
?
3,4-cis-leucoanthocyanidin + NADPH
-
636457
Desmodium uncinatum
2,3-trans-catechin + NADP+ + H2O
no formation of 2,3-cis-epicatechin
-
-
?
3,4-cis-leucodelphinidin + NADPH
-
636457
Desmodium uncinatum
? + NADP+ + H2O
-
-
-
?
3,4-cis-leucodelphinidin + NADPH
-
636457
Desmodium uncinatum
2,3-trans-gallocatechin + NADP+ + H2O
-
-
-
?
3,4-cis-leucopelargonidin + NADPH
-
636457
Desmodium uncinatum
? + NADP+ + H2O
-
-
-
?
3,4-cis-leucopelargonidin + NADPH
-
636457
Desmodium uncinatum
2,3-trans-afzelechin + NADP+ + H2O
-
-
-
?
additional information
enzyme is involved in the biosynthesis of condensed tannins or proanthocyanidins 3,4-cis-leucoanthocyanidin, first committed step, anthocyanidin pathway overview
636457
Desmodium uncinatum
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
monomer
1 * 45000, native enzyme, SDS-PAGE; 1 * 45000, SDS-PAGE
Desmodium uncinatum
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Desmodium uncinatum
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
; broad optimum
Desmodium uncinatum
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6.2
7.8
95% activity at pH 6.2 and pH 7.8; 95% of maximal activity at pH 76.2 and pH 7.8
Desmodium uncinatum
Cofactor
Cofactor
Commentary
Organism
Structure
NADH
30% the rate of NADPH
Desmodium uncinatum
NADPH
;
Desmodium uncinatum
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
additional information
-
additional information
-
Desmodium uncinatum
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Desmodium uncinatum
determination of DNA and amino acid sequences, expression in Escherichia coli strain XL-1 Blue, Nicotiana tabacum, and Trifolium repens, plant transformations via Agrobacterium tumefaciens infection system
Desmodium uncinatum
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADH
30% the rate of NADPH
Desmodium uncinatum
NADPH
-
Desmodium uncinatum
Crystallization (Commentary) (protein specific)
Crystallization
Organism
near homogeneity
Desmodium uncinatum
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2,3-cis-flavan-3,4-diol
slight inhibition
Desmodium uncinatum
2,3-cis-flavan-3-ol
product inhibition
Desmodium uncinatum
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromenium
48% inhibition at 0.006 mM
Desmodium uncinatum
3,4-trans-leucocyanidin
50% inhibition at 0.12 mM
Desmodium uncinatum
3,4-trans-leucopelargonidin
50% inhibition at 0.46 mM
Desmodium uncinatum
afzelechin
50% inhibition at 0.014 mM
Desmodium uncinatum
catechin
50% inhibition at 0.012 mM
Desmodium uncinatum
delphinidin
97% inhibition at 0.06 mM
Desmodium uncinatum
dihydroquercetin
60% inhibition at 0.01 mM
Desmodium uncinatum
epi-gallocatechin
50% inhibition at 1.4 mM
Desmodium uncinatum
eriodictyol
53% inhibition at 0.01 mM
Desmodium uncinatum
gallocatechin
50% inhibition at 0.28 mM
Desmodium uncinatum
additional information
overview: phenylpropanoids
Desmodium uncinatum
NADP+
50% inhibition at 0.5 mM
Desmodium uncinatum
NADP+
slight inhibition
Desmodium uncinatum
pelargonidin
55% inhibition at 0.006 mM
Desmodium uncinatum
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
additional information
-
additional information
-
Desmodium uncinatum
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0004
-
NADPH
pH 7.0, 30°C
Desmodium uncinatum
0.005
-
3,4-cis-leucodelphinidin
pH 7.0, 30°C
Desmodium uncinatum
0.006
-
2,3-trans-3,4-cis-leucocyanidin
pH 7.0, 30°C
Desmodium uncinatum
0.006
-
3,4-cis-leucoanthocyanidin
pH 7.0, 30°C
Desmodium uncinatum
0.026
-
3,4-cis-leucopelargonidin
pH 7.0, 30°C
Desmodium uncinatum
0.06
-
NADH
pH 7.0, 30°C
Desmodium uncinatum
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
45000
-
1 * 45000, SDS-PAGE
Desmodium uncinatum
45000
-
1 * 45000, native enzyme, SDS-PAGE
Desmodium uncinatum
52000
-
gel filtration
Desmodium uncinatum
52000
-
native enzyme, gel filtration
Desmodium uncinatum
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2,3-trans-3,4-cis-leucocyanidin + NADPH
Desmodium uncinatum
-
(2R,3S)-catechin + NADP+ + H2O
-
-
-
3,4-cis-leucoanthocyanidin + NADPH
Desmodium uncinatum
-
2,3-trans-catechin + NADP+ + H2O
no formation of 2,3-cis-epicatechin
-
?
additional information
Desmodium uncinatum
enzyme is involved in the biosynthesis of condensed tannins or proanthocyanidins 3,4-cis-leucoanthocyanidin, first committed step, anthocyanidin pathway overview
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
native enzyme to near homogeneity from leaves, about 48500fold
Desmodium uncinatum
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
leaf
-
Desmodium uncinatum
-
leaf
small unexpanded leaflets
Desmodium uncinatum
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
8.7
-
-
Desmodium uncinatum
8.7
-
purified native enzyme, substrate 2,3-trans-3,4-cis-leucoanthocyanidin
Desmodium uncinatum
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2,3-trans-3,4-cis-leucocyanidin + NADPH
-
636457
Desmodium uncinatum
(2R,3S)-catechin + NADP+ + H2O
-
-
-
-
2,3-trans-3,4-cis-leucocyanidin + NADPH
-
636457
Desmodium uncinatum
(2R,3S)-catechin + NADP+ + H2O
-
-
-
?
3,4-cis-leucoanthocyanidin + NADPH
-
636457
Desmodium uncinatum
2,3-trans-catechin + NADP+ + H2O
no formation of 2,3-cis-epicatechin
-
-
?
3,4-cis-leucodelphinidin + NADPH
-
636457
Desmodium uncinatum
? + NADP+ + H2O
-
-
-
?
3,4-cis-leucodelphinidin + NADPH
-
636457
Desmodium uncinatum
2,3-trans-gallocatechin + NADP+ + H2O
-
-
-
?
3,4-cis-leucopelargonidin + NADPH
-
636457
Desmodium uncinatum
? + NADP+ + H2O
-
-
-
?
3,4-cis-leucopelargonidin + NADPH
-
636457
Desmodium uncinatum
2,3-trans-afzelechin + NADP+ + H2O
-
-
-
?
additional information
enzyme is involved in the biosynthesis of condensed tannins or proanthocyanidins 3,4-cis-leucoanthocyanidin, first committed step, anthocyanidin pathway overview
636457
Desmodium uncinatum
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
1 * 45000, SDS-PAGE
Desmodium uncinatum
monomer
1 * 45000, native enzyme, SDS-PAGE
Desmodium uncinatum
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Desmodium uncinatum
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
-
Desmodium uncinatum
7
-
broad optimum
Desmodium uncinatum
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6.2
7.8
95% activity at pH 6.2 and pH 7.8
Desmodium uncinatum
6.2
7.8
95% of maximal activity at pH 76.2 and pH 7.8
Desmodium uncinatum
Other publictions for EC 1.17.1.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746163
Wang
Evolutionary and functional c ...
Camellia sinensis
Planta
247
139-154
2018
-
-
1
-
-
-
-
-
-
-
-
3
-
9
-
-
-
-
-
5
-
-
3
1
-
-
-
-
-
-
-
1
-
3
-
-
-
3
3
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
15
-
-
3
3
-
-
-
-
-
-
-
3
-
3
9
-
-
-
743899
Kumar
Pyramiding of tea dihydroflav ...
Camellia sinensis
3 Biotech
7
177
2017
-
-
1
-
1
-
-
-
-
-
-
1
-
5
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
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-
1
1
-
1
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-
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-
1
-
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-
-
-
1
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-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
745825
Zhao
Metabolic characterization of ...
Camellia sinensis
Molecules
22
E2241
2017
-
-
1
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
1
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1
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1
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1
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1
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1
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-
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-
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1
1
-
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745634
Matsui
Isolation and characterizatio ...
Fagopyrum esculentum
J. Plant Physiol.
205
41-47
2016
-
-
1
-
-
-
-
-
-
-
-
3
-
3
-
-
-
-
-
8
-
-
3
-
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-
-
-
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1
-
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3
3
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3
-
-
-
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-
24
-
-
3
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
745869
Liu
A role for leucoanthocyanidin ...
Medicago truncatula, Medicago truncatula ecotype R108
Nat. Plants
2
16182
2016
-
-
1
-
2
-
-
-
-
-
-
4
-
4
-
-
-
-
-
1
-
-
6
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
6
-
1
-
-
-
1
-
-
-
1
3
3
1
-
-
746116
Nemesio-Gorriz
Different alleles of a gene e ...
Picea abies
Plant Physiol.
171
2671-2681
2016
-
-
1
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
-
-
-
1
-
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-
-
-
-
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-
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1
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-
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1
-
-
-
-
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1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
744993
Liao
Molecular characterization of ...
Malus asiatica, Malus asiatica Nakai, Malus domestica, Malus prunifolia, Malus sikkimensis
Front. Plant Sci.
6
243
2015
-
-
4
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
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-
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-
-
-
-
-
-
-
-
-
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
12
15
-
-
-
745035
Wen
Accumulation of flavanols and ...
Vitis vinifera
Genet. Mol. Res.
14
7687-7695
2015
-
-
1
-
-
-
-
-
-
-
-
2
-
3
-
-
-
-
-
2
-
-
4
-
1
-
-
-
1
-
-
1
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
4
-
2
-
-
-
2
-
-
-
1
-
-
2
-
-
728635
Xiao
Transcriptome and biochemical ...
Gossypium hirsutum
PLoS ONE
9
e86344
2014
-
-
-
-
-
-
-
-
-
-
-
-
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2
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-
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-
-
-
-
-
-
-
1
-
-
1
-
-
746499
Kim
Transcripts of anthocyanidin ...
Fagopyrum tataricum
ScientificWorldJournal
2014
726567
2014
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
9
-
-
1
1
-
-
-
-
-
-
-
1
-
1
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
1
-
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