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Literature summary for 1.16.3.1 extracted from

  • Mak, C.M.; Lam, C.W.; Tam, S.
    Diagnostic accuracy of serum ceruloplasmin in Wilson disease: determination of sensitivity and specificity by ROC curve analysis among ATP7B-genotyped subjects (2008), Clin. Chem., 54, 1356-1362.
    View publication on PubMed

Application

Application Comment Organism
medicine serum ceruloplasmin concentrations of less than 0.20, of 0.14 and 0.10 g per l show positive predictive values of 48.3%, 100%, and 100%, respectively, for Wilson disease, and negative predictive values of 98.7%, 97.1%, and 91.9%, with measurement of ceruloplasmin concentration according to a nephelometric method, in ATP7B genotyped subjects. The diagnostic accuracy for Wilson disease using a serum ceruloplasmin concentration of 0.14 g per l as the local decision threshold is therefore better than using a threshold of 0.20 g per l Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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patients with Wilson disease and ATP7B genotypes
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