Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.16.1.8 extracted from

  • Yamada, K.; Gravel, R.A.; Toraya, T.; Matthews, R.G.
    Human methionine synthase reductase is a molecular chaperone for human methionine synthase (2006), Proc. Natl. Acad. Sci. USA, 103, 9476-9481.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.16.1.8

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 expression by baculovirus-infected insect cells
-

Purification (Commentary)

Purification (Comment) Organism
after expression by baculovirus-infected insect cells. the flavin mononuleotide cofactor dissociates readily from enzyme upon dilution, hence it is important to keep the concentration high during purification Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[methionine synthase]-cob(II)alamin + NADPH + S-adenosylmethionine in presence of methionine synthase reductase, holoenzyme formation from apomethionine synthase and methylcobalamin is significantly enhanced due to stabilization of apomethionine synthase. In addition to reductase activity, methionine synthase reductase serves as a special chaperone for methionine synthase. It also has reductase activity for the reaction of aquacobalamin to cob(II)alamin Homo sapiens [methionine synthase]-methylcob(I)alamin + NADPH + S-adenosylhomocysteine
-
 ?

Subunits

Subunits Comment Organism
More in addition to reductase activity, methionine synthase reductase serves as a special chaperone for methionine synthase Homo sapiens