Protein Variants | Comment | Organism |
---|---|---|
C13S | destruction of native Fe(SCys)4 site with complete loss of its iron, no enzymic activity. Fe(NHis)4(SCys) site and protein homodimer remain intact | Desulfovibrio vulgaris |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | - |
Desulfovibrio vulgaris |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Desulfovibrio vulgaris | in times of oxidative stress, enzyme efficiently diverts intracellular reducing equivalents to superoxide | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Desulfovibrio vulgaris | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin | presence of Fe(NHis)4(SCys) site is sufficient to catalyze reduction of the intracellular superoxide to nonlethal levels | Desulfovibrio vulgaris | |
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin | steady state kinetics, diffusion-controlled reaction of reduced enzyme with superoxide is the slowest process during turnover, neither ligation nor deligation of the active site carboxylate limits turnover rate | Desulfovibrio vulgaris |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | in times of oxidative stress, enzyme efficiently diverts intracellular reducing equivalents to superoxide | Desulfovibrio vulgaris | ? | - |
? |