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Literature summary for 1.15.1.1 extracted from
- Purification of Cu/Zn superoxide dismutase from Piper betle leaf and its characterization in the oral cavity (2015), J. Agric. Food Chem., 63, 2225-2232 .
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | a Cu/Zn SOD | Piper betle |  |
| Zn2+ | a Cu/Zn SOD | Piper betle | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 superoxide + 2 H+ | Piper betle | - |
O2 + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Piper betle | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from leaves to apparent homogeneity | Piper betle |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Piper betle | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 superoxide + 2 H+ | - |
Piper betle | O2 + H2O2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 15700, SDS-PAGE | Piper betle |
| monomer | 1 * 15700, SDS-PAGE | Piper betle |
| More | the purified SOD appears to be monomeric and converts to its dimeric form with increased enzymatic activity in betel nut oral extract. This irreversible conversion is mainly induced by slaked lime, resulting from the increase in pH of the oral cavity. Oral extract from chewing areca nut alone also induces SOD dimerization due to the presence of arginine | Piper betle |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cu/Zn SOD | - |
Piper betle |
| Cu/Zn superoxide dismutase | - |
Piper betle |
| SOD | - |
Piper betle |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Piper betle |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enhanced activity of the SOD dimer in betel nut oral extract is responsible for the continuous production of hydrogen peroxide in the oral cavity. SOD may contribute to oral carcinogenesis through the continuous formation of hydrogen peroxide in the oral cavity, in spite of its protective role against cancer in vivo | Piper betle |
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